ArticleFrontiers in dental medicine2025
Effects of cavity depth (moderate vs. deep with pulp exposure) on the release of prostaglandin E2 and nitric oxide in rat mandibular incisors.
Article in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background/objectives: Inflammatory mediators such as prostaglandin E2 (PGE2) and nitric oxide (NO) are key indicators of pulp response to mechanical trauma. However, the influence of cavity depth on their release dynamics remains unclear. This study aimed to evaluate the effects of different cavity depths-moderate (without pulp exposure) and deep (with pulp exposure)-on the release of PGE2 and NO in the pulp tissue of rat mandibular incisors at two time intervals (3 and 9 h). Methods: In total, 40 male Wistar rats were divided into two main groups ( Results: Cavities without pulp exposure elicited 2.1-fold higher PGE2 (median: 3.44 vs. 1.81 ng/mL; Conclusion: Cavity preparation induces an early inflammatory response in the pulp, as indicated by increased PGE2 and NO levels. The inflammatory response was more pronounced in cavities without pulp exposure, suggesting that maintaining pulp integrity favors a regulated inflammatory response conducive to healing, while exposure may promote irreversible damage.
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