Evidence map›Paper›PMID 41257029›Full record

ReviewReproductive medicine and biology

The Genetic Landscape of Müllerian Duct Anomalies: A Comprehensive Review.

Lin He, Shuya Chen, Yujun Sun, Zhi Zheng, Yuxiao Li, Chunfang Chu, Lin Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lin HeCentral Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China.
Shuya ChenCentral Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China.ORCID https://orcid.org/0000-0001-9979-7408
Yujun SunCentral Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China.
Zhi ZhengCentral Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China.
Yuxiao LiCentral Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China.
Chunfang ChuDepartment of Gynecology Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China.
Lin LiCentral Laboratory Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital Beijing China.ORCID https://orcid.org/0000-0002-3597-3350

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Müllerian duct anomalies (MDAs) are developmental malformations of the female genital tract that present as a series of abnormalities within the reproductive tracts of females. The etiology of MDAs is complex and heterogeneous, especially genetic factors. Methods: We conducted a comprehensive literature search in PubMed to identify relevant research articles and reviews. The search primarily targeted English-language publications from January 1978 to June 2025. Key search terms included Müllerian duct anomalies, Müllerian duct development, candidate gene, genetic, epigenetic, whole-exome sequencing, DNA methylation, chromosome, and related keywords. Results: This review provides a comprehensive overview of the genetic factors and mechanisms underlying human Müllerian duct development. It systematically examines the genetic mutations and other mechanisms contributing to Müllerian duct anomalies (MDAs), including candidate genes and epigenetic abnormalities. Furthermore, the review summarizes recent advances in MDAs research and the digenic mode of inheritance. Conclusion: We summarized the current genetic status of MDAs and discussed the research progress of relevant candidate genes in recent years in detail, and reviewed the reasons hindering progress in the field of MDAs.

Indexed as

candidate genescopy number variationsgenetic factorsMüllerian duct anomaliesvariants

Identifiers

PMID41257029
PMCPMC12621114

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.