Evidence map›Paper›PMID 41257010›Full record

ArticleACS medicinal chemistry letters2025

Restructuring Antiviral Quinazolinone Frameworks to Derive and Optimize Inhibitors of Chikungunya Virus.

Caroline M Roach, Zachary J Streblow, Yuting Zhang, Tyler J Ogorek, Alejandro Ponce-Flores, Colleen B Jonsson, Daniel N Streblow, Jennifer E Golden

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caroline M RoachDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID https://orcid.org/0009-0009-7643-5848
Zachary J StreblowVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, United States.
Yuting ZhangRegional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Tyler J OgorekDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Alejandro Ponce-FloresDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
Colleen B JonssonRegional Biocontainment Laboratory, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.ORCID https://orcid.org/0000-0002-2640-7672
Daniel N StreblowVaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon 97006, United States.
Jennifer E GoldenDivision of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID https://orcid.org/0000-0002-6813-3710

Funding

Research Project 1: Coronavirus antiviral lead development and combination testingU19AI171292 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, WILLSON, TIMOTHY M · 2022 to 2022
$65.5M
Accelerated discovery of cell-active SARS-CoV-2 polymerase inhibitors via molecular dynamic guided screening and optimizationR21AI161232 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDEN, JENNIFER E. · 2021 to 2021
$443k
NIAID NIH HHS R21 AI161232NIAID NIH HHS U19 AI171292
6 · The paper itself

Abstract

Chikungunya virus (CHIKV) results in debilitating chronic pain in nearly half of those infected. With no FDA approved small molecule-based therapeutics available, we screened compounds to reveal quinazolinone (

Indexed as

alphaviruschikungunyainhibitorquinazolinone

Identifiers

PMID41257010
PMCPMC12621019

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.