Evidence map›Paper›PMID 41256976›Full record

ArticleACS medicinal chemistry letters2025

Structure-Based Ligandability Exploration of a G‑Quadruplex-Forming Sequence from the

Martina Fiabane, Chiara Platella, Fabiana Diaco, Cristiano Biancucci, Andrea Calcaterra, Domenica Musumeci, Guido Antonelli, Ombretta Turriziani, Bruno Botta, Daniela Montesarchio and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Martina FiabaneDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena 53100, Italy.ORCID https://orcid.org/0009-0009-2438-9018
Chiara PlatellaDepartment of Chemical Sciences, University of Naples Federico II, Napoli 80126, Italy.ORCID https://orcid.org/0000-0002-6997-1767
Fabiana DiacoDepartment of Molecular Medicine, Laboratory of Microbiology and Virology, Sapienza University of Rome, Rome 00185, Italy.
Cristiano BiancucciDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Rome 00185, Italy.
Andrea CalcaterraDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Rome 00185, Italy.ORCID https://orcid.org/0000-0001-7036-6620
Domenica MusumeciDepartment of Chemical Sciences, University of Naples Federico II, Napoli 80126, Italy.ORCID https://orcid.org/0000-0001-7624-1933
Guido AntonelliDepartment of Molecular Medicine, Laboratory of Microbiology and Virology, Sapienza University of Rome, Rome 00185, Italy.
Ombretta TurrizianiDepartment of Molecular Medicine, Laboratory of Microbiology and Virology, Sapienza University of Rome, Rome 00185, Italy.
Bruno BottaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, Rome 00185, Italy.ORCID https://orcid.org/0000-0001-8707-4333
Daniela MontesarchioDepartment of Chemical Sciences, University of Naples Federico II, Napoli 80126, Italy.
Mattia MoriDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena 53100, Italy.ORCID https://orcid.org/0000-0003-2398-1254

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial G-quadruplexes (G4s) are related to survival and resistance mechanisms in several pathogens, making them attractive targets for innovative antimicrobials. However, little structural and ligand binding information is available so far. Based on the structure of the TET22 G4 from

Indexed as

antibacterial agentsG-quadruplexPseudomonas aeruginosastabilizersTET22

Identifiers

PMID41256976
PMCPMC12621014

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.