Comparison of Two Topical Pharmacological Agents in Alleviating Peripheral Intravenous Catheterization Induced Pain in Adults: A Randomized Controlled Study.

Objective: This study aimed to evaluate the efficacy of the topical anesthetics lidocaine and benzocaine in reducing pain associated with peripheral intravenous catheterization and in enhancing patient satisfaction in the emergency department. Materials and Methods: This randomized-controlled, parallel-group, double-blind, experimental, and Phase III clinical trial involved 120 individuals admitted to the Emergency Department of a University Hospital. Data were collected using an Individual Information Form, Visual Analog Scale, and Patient Satisfaction Scale about Catheterization. Participants were divided into three groups (lidocaine 10% spray, benzocaine 20% spray, and placebo groups) according to a computer-generated randomization table. Results: The average pain scores were lower and satisfaction levels with catheterization were higher in the lidocaine and benzocaine groups compared to the placebo group (p<0.001). A strong negative correlation was observed between the groups' pain scores and satisfaction levels with catheterization (Lidocaine Spray Group r=-0.636 p<0.001; Benzocaine Spray Group r=-0.651 p<0.001; Placebo Group r=-0.877 p<0.001). Conclusion: Topical lidocaine and benzocaine have been proven to reduce pain from peripheral intravenous catheterization and improve patient satisfaction. These agents can be routinely used to alleviate injection pain and improve patient satisfaction with the procedure.