ArticleFrontiers in psychiatry2025
Admission uric acid to HDL-C ratio predicts 90-day post-stroke depression in acute ischemic stroke.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Molecular biomarkers of cognitive impairment and neuropsychiatric symptoms after stroke in late-life-enriched cohorts: a scoping review.Journal of translational medicine · 2026Article
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5 authors.
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Abstract
Background: Post-stroke depression (PSD) affects 30% of acute ischemic stroke (AIS) survivors, compromising functional recovery and increasing mortality. Uric acid (UA) and high-density lipoprotein cholesterol (HDL) modulate oxidative stress and neuroinflammation, but their individual prognostic value is inconsistent. This study investigated whether the admission UA/HDL ratio (UHR) independently predicts 90-day PSD in AIS patients. Methods: We retrospectively analyzed 541 AIS patients admitted to Shanxi Bethune Hospital (October 2023-December 2024). Inclusion required first-ever AIS confirmed by CT or MRI within 72 hours. Demographics, clinical variables, and laboratory data were collected. Multivariable logistic regression, subgroup analyses, and restricted cubic spline models evaluated associations between UHR and PSD, adjusting for confounders. Results: Of 541 patients, 193 (35.7%) developed PSD. PSD patients had higher UHR, elevated NIHSS scores, reduced neutrophil counts, and lower cognitive scores (all p<0.05). UHR independently predicted PSD (adjusted OR per 1-unit increase: 1.0023 and per 1-SD increase: 1.4725; p=0.0042). Patients in the highest UHR quartile had a 2.17-fold higher PSD risk versus the lowest quartile (p=0.044), with a significant linear dose-response (p=0.013). Subgroup analyses confirmed consistent associations across stroke severity, sex, and comorbidities. Conclusions: Admission UA/HDL ratio is a robust, independent predictor of 90-day PSD in AIS patients. As an accessible, cost-effective marker, UHR may enable early identification of high-risk individuals during the acute post-stroke phase.
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