ArticleSmart medicine2025
Ultrasound-Responsive Microcapsules Delivering Oxygen and Traditional Chinese Medicine for Wound Healing.
Article in Smart medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Sprayable bioadhesive microcarriers loaded with Tβ4-Engineered ADSC exosomes for diabetic wound healing.Bioactive materials · 2026Article
- Ultrasound-responsive composite hydrogels: Design rules for spatiotemporally controlled drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- Hepatocellular Carcinoma-on-a-Chip Based on Microfluidic Well Array for Personalized Drug Evaluation.Advanced healthcare materials · 2026Article
- Microneedle-Assisted Cell Delivery and Therapy.Research (Washington, D.C.) · 2026Review
- Ultrasound-Responsive Microcapsules Delivering Oxygen and Traditional Chinese Medicine for Wound Healing.Smart medicine · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogel microparticles with different actives encapsulation have reliable efficacy in wound repair, and the challenge is to improve the active substance to improve the efficacy. Here, a novel ultrasonic responsive core-shell microcapsule delivery system is proposed, which can simultaneously load traditional Chinese medicine sonosensitizer and oxygen synergistic effect to promote the healing of infected wounds. The microcapsule has a core of oxygen-rich perfluorocarbon (PO) and a hydrogel shell with curcumin (PO/C-MC). Ultrasound can trigger the release of oxygen from perfluorocarbon and stimulate the sonodynamic effect of curcumin, which is not only an anti-inflammatory traditional Chinese medicine but also a sonosensitizer, thus realizing the synergistic treatment of traditional Chinese medicine and acoustic dynamics. Under the irradiation of low-intensity ultrasound, PO/C-MCs can effectively increase the oxygen concentration and enhance the antibacterial effect of sonodynamic therapy, synergizing with the anti-inflammatory effect of traditional Chinese medicine to promote the rapid healing of chronic infected wounds. The study demonstrated that ultrasound-responsive PO/C-MCs microcapsules significantly enhanced the healing process of infected wounds in mice. Given these beneficial characteristics, PO/C-MCs represent a promising therapeutic candidate with considerable potential for clinical application in managing chronic infected wounds.
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