ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Elevated Serum Tsukushi Levels and Their Association with Glycolipid Metabolism in Gestational Diabetes Mellitus Patients.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Tsukushi (TSK) is a recently identified hepatic factor that has gained prominence for its distinctive function in glycolipid metabolism and energy homeostasis. However, the role of TSK in gestational diabetes mellitus (GDM) remains largely unexplored. In this study, we conducted a pioneering investigation by determining serum TSK levels in patients with GDM and examining the correlation between these levels and various metabolic parameters in gestational diabetes patients. Methods: A total of 176 pregnant women (mean age 29.5 ± 3.2 years) were recruited from September 2023 to December 2024. Serum TSK levels and clinical markers related to glycolipid metabolism were measured at 24-28 weeks of gestation. All subjects underwent an oral glucose tolerance test (OGTT). Results: Serum TSK was significantly higher in patients with GDM than in the normal glucose tolerance group [0.60(0.47,0.73 vs 0.52(0.42,0.67) ng/mL; Conclusion: TSK levels were higher in GDM than in NGT (P=0.013), and higher TSK tertiles were independently associated with increased odds of GDM (Model 3 OR=2.883, 95% CI 1.173-7.084; P=0.021). After FDR correction, only the association with total cholesterol remained significant (FDR-adjusted P=0.023).
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