ArticleClinical ophthalmology (Auckland, N.Z.)2025
The Role of the Vitreous Zonule in Preoperative Diagnosis of Zonular Laxity in Primary Angle-Closure Disease.
Article in Clinical ophthalmology (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Comment on "The Role of the Vitreous Zonule in Preoperative Diagnosis of Zonular Laxity in Primary Angle-Closure Disease" [Letter].Clinical ophthalmology (Auckland, N.Z.) · 2025Article
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7 authors.
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Abstract
Purpose: This study aimed to evaluate the diagnostic value of the number of visible vitreous zonule (VZ) quadrants in predicting zonular laxity in patients with primary angle-closure disease (PACD). Patients and Methods: This prospective cohort study collected data between the period of November 2021 and February 2024. PACD patients were enrolled, with one eye selected randomly for analysis. The main outcome was the association between the presence/number of quadrants with visible VZ and the presence of zonular laxity. The diagnostic capability of the number of quadrants with VZ in determining zonular laxity was evaluated. Results: A total of 50 patients were enrolled in the study. Compared with the VZ group, the no VZ group was more likely to manifest zonula laxity (14 of 14 [100%] vs 19 of 36 [53%], P = 0.002). The zonular laxity group had fewer quadrants with visible VZ (1.18 ± 0.22 vs 2.93 ± 0.22, P < 0.001) than the normal group. The number of quadrants for zonular laxity detection achieved an area under the curve of 0.855 (P < 0.001). The highest Youden Index was observed when the number of quadrants was less than 3, indicating superior diagnostic capability for zonular laxity, with a sensitivity of 84.9% and specificity of 70.6%. The highest sensitivity (93.9%) was achieved when the number of quadrants was less than 4. Conclusion: The study found a link between VZ lack and zonular laxity in PACD, enhancing diagnosis with fewer VZ quadrants, and highlighted VZ's diagnostic value.
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