Evidence map›Paper›PMID 41256861›Full record

ArticleFrontiers in immunology2025

The impact of low-dose gamma radiation on immune modulation in a mouse model of spontaneous mammary gland tumorigenesis.

Abrar Ul Haq Khan, Melinda Blimkie, Bryan Marr, Jin Wu, Tyler Pack, Shelby Kaczmarek, Dong-Hyeon Jo, Holly Laakso, Seung-Hwan Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abrar Ul Haq KhanDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Melinda BlimkieRadiobiology and Health Branch, Canadian Nuclear Laboratories Ltd., Chalk River, ON, Canada.
Bryan MarrDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Jin WuRadiobiology and Health Branch, Canadian Nuclear Laboratories Ltd., Chalk River, ON, Canada.
Tyler PackRadiobiology and Health Branch, Canadian Nuclear Laboratories Ltd., Chalk River, ON, Canada.
Shelby KaczmarekDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Dong-Hyeon JoDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Holly LaaksoRadiobiology and Health Branch, Canadian Nuclear Laboratories Ltd., Chalk River, ON, Canada.
Seung-Hwan LeeDepartment of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the impacts of low-dose ionizing radiation exposure has significant public health implications. However, the effects of low-dose ionizing radiation on immune modulation and cancer progression remain contentious. This study aimed to investigate the impact of chronic low-dose gamma radiation on mammary tumorigenesis and immune homeostasis using a transgenic mouse model. Female MMTV-neu transgenic mice were exposed to continuous whole-body

Indexed as

CarcinogenesisGamma RaysImmunomodulationMammary Neoplasms, ExperimentalAnimalsCytokinesDisease Models, AnimalDose-Response Relationship, RadiationFemaleKiller Cells, NaturalMiceMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KCytokinesKlrk1 protein, mouseNK Cell Lectin-Like Receptor Subfamily KinflammationLDRLNTNK cellsNKG2Dtumor

Identifiers

PMID41256861
PMCPMC12620402

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.