Evidence map›Paper›PMID 41256713›Full record

ArticlebioRxiv : the preprint server for biology2025

Transdiagnostic connectome-based predictive modeling of many behavioral phenotypes reveals brain network mediators of clinical-cognitive relationships.

Alexander J Simon, Anja Samardzija, Santino Iannone, Flor Parra Rodriguez, Saloni Mehta, Jagriti Arora, Fuyuze Tokoglu, Maolin Qiu, Kira Y Tang, Anna Q Flanagan and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alexander J SimonInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7087-7965
Anja SamardzijaDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Santino IannoneInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
Flor Parra RodriguezDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Saloni MehtaDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Jagriti AroraDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Fuyuze TokogluDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Maolin QiuDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Kira Y TangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Anna Q FlanaganDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Rachel KatzDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Gerard SanacoraDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Scott W WoodsDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Vinod H SrihariDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Xilin ShenDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Dustin ScheinostInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.
R Todd ConstableInterdepartmental Neuroscience Program, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5661-9521

Funding

An Individualized, Multidimensional Dimensional Approach to PsychopathologyR01MH121095 · NIMH · YALE UNIVERSITY · PI CONSTABLE, R TODD, SCHEINOST, DUSTIN · 2019 to 2023
$4.2M
NIMH NIH HHS R01 MH121095
6 · The paper itself

Abstract

Connectome-based predictive modeling (CPM) applied to functional MRI connectivity data can identify brain networks that vary with behavioral measures across subjects. The prediction strength also provides an index of how closely an external instrument relates to specific brain networks, potentially impacting their clinical interpretation. Here we use a deeply phenotyped transdiagnostic population (

Identifiers

PMID41256713
PMCPMC12621800

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.