Evidence map›Paper›PMID 41256692›Full record

ArticlebioRxiv : the preprint server for biology2025

From Neuropeptides to Toxins: Illuminating the Origins of Venom Complexity in Cone Snails.

Thomas Lund Koch, Giada Ferrari, Sunita B Sumanam, Paula Flórez Salcedo, Maren Watkins, Kevin Chase, Ave Tooming-Klunderud, Arturo O Lluisma, Angel Yanagihara, Neil D Young and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Thomas Lund KochDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Giada FerrariCentre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0316 Oslo, Norway.
Sunita B SumanamMelbourne Veterinary School, The University of Melbourne, Parkville,3552, Victoria, Australia.
Paula Flórez SalcedoDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.
Maren WatkinsSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Kevin ChaseSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Ave Tooming-KlunderudCentre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0316 Oslo, Norway.
Arturo O LluismaThe Marine Science Institute, University of the Philippines, Diliman, Quezon City 1101, Philippines.
Angel YanagiharaDepartment of Tropical Medicine, Medical Microbiology and Pharmacology, University of Hawaii, Honolulu, HI 96822, USA.
Neil D YoungMelbourne Veterinary School, The University of Melbourne, Parkville,3552, Victoria, Australia.
Baldomero M OliveraSchool of Biological Sciences, University of Utah, Salt Lake City, UT 84112, USA.
Eivind A B UndheimCentre for Ecological and Evolutionary Synthesis, Department of Biosciences, University of Oslo, 0316 Oslo, Norway.
Helena Safavi-HemamiDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA.

Funding

UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
“Conus venom peptides and their molecular targets: Using pharmaconomics and neuroethology as a framework for discovery”R01GM144719 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI OLIVERA, BALDOMERO M, RAGHURAMAN, SHRINIVASAN · 2022 to 2025
$2.5M
NCI NIH HHS P30 CA042014NIGMS NIH HHS R01 GM144719
6 · The paper itself

Abstract

New genes and gene functions are key drivers of evolutionary innovation. Venomous animals, such as cone snails, provide striking examples of gene innovation, yet the mechanisms by which toxins arise remain poorly understood. Using the

Identifiers

PMID41256692
PMCPMC12621736

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.