Evidence map›Paper›PMID 41256682›Full record

ArticlebioRxiv : the preprint server for biology2025

Fibroblast orchestration of inflammaging via NF-kB activation.

Nancy C Allen, Christian Ringler, Jin Young Lee, Nabora Reyes, Ritusree Biswas, Sofia Caryotakis, Melia Magnen, Pedro Ruivo, Vincent Auyeung, Mark Looney and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nancy C AllenDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.
Christian RinglerDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.
Jin Young LeeDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.
Nabora ReyesDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.
Ritusree BiswasDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.
Sofia CaryotakisImmunoX Initiative and Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94143.
Melia MagnenDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.
Pedro RuivoComparative Pathology Laboratory, School of Veterinary Medicine, University of California Davis, Davis, CA 95616.
Vincent AuyeungDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.ORCID 0000-0001-6273-1595
Mark LooneyDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.
Averil MaDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.
Ari B MolofskyImmunoX Initiative and Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94143.
Tien PengDepartment of Medicine, Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California San Francisco, San Francisco, CA 94143.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Deciphering the role of p16INK4A+ fibroblasts in lung fibrosisR01HL160895 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PENG, TIEN · 2022 to 2025
$2.2M
IRE1α mediated dysregulation of the pulmonary epithelium in lung fibrosisK08HL157654 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AUYEUNG, VINCENT CHURK-MAN · 2021 to 2025
$874k
Role of stromal inflammatory signaling in the aging of lung resident lymphocytesK08HL169723 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nancy Christine Allen · 2023 to 2026
$676k
Mesenchymal inflammatory signaling in regulation of the immune response and tissue dysfunction during lipopolysaccharide-induced acute lung injuryF32HL156452 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALLEN, NANCY CHRISTINE · 2022 to 2023
$103k
NHLBI NIH HHS F32 HL156452NHLBI NIH HHS K08 HL157654NHLBI NIH HHS K08 HL169723NHLBI NIH HHS R01 HL160895NIDDK NIH HHS P30 DK063720NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

Aged tissue is characterized by chronic inflammation known as "inflammaging". While this aging immune phenotype supposedly drives some of the most common diseases affecting the elderly, little is known about the structural drivers of inflammaging. In this study, we demonstrate that age-dependent activation of NF-kB in tissue fibroblasts remodels the immune architecture, promoting the emergence of an exhausted T cell population (GZMK

Indexed as

adventitiaaged lungARDSfibroblastsGZMK+ T cellsimmune agingInflammagingNF-kBT cell exhaustiontertiary lymphoid structureTNFAIP3

Identifiers

PMID41256682
PMCPMC12622043

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.