Evidence map›Paper›PMID 41256678›Full record

ArticlebioRxiv : the preprint server for biology2025

Dim light at night impacts circadian rhythms and Alzheimer's disease-like neuroinflammation and neuropathology in humanized APP SAA knock-in mice.

Marilyn J Duncan, Margaret R Hawkins, Leke Bytyqi, Haleigh R Whitlock, Savannah Shepard, MaKayla F Cox, Esther G Drinkard, Teresa Macheda, Kelly N Roberts, Katherina Kohler and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Marilyn J DuncanDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Margaret R HawkinsDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Leke BytyqiDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Haleigh R WhitlockDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Savannah ShepardSpinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY, USA.
MaKayla F CoxDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Esther G DrinkardDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Teresa MachedaDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Kelly N RobertsDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Katherina KohlerDepartment of Molecular & Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.
Mary-Claire SchmidtDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.
Carrie E JohnsonDepartment of Molecular & Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.
Sridhar SunderamDepartment of Biomedical Engineering, University of Kentucky, Lexington, KY, USA.
Bruce F O'HaraDepartment of Biology, University of Kentucky, Lexington, KY, USA.
Michael P MurphyDepartment of Molecular & Cellular Biochemistry, University of Kentucky, Lexington, KY, USA.
Adam D BachstetterDepartment of Neuroscience, University of Kentucky, Lexington, KY, USA.ORCID 0000-0003-4646-6757

Funding

Sleep Fragmentation and Alzheimer’s DiseaseR01AG068215 · NIA · UNIVERSITY OF KENTUCKY · PI BACHSTETTER, ADAM D, DUNCAN, MARILYN J. · 2020 to 2024
$3.8M
Training in Translational Research in Alzheimer's and Related Dementias (TRIAD)T32AG078110 · NIA · UNIVERSITY OF KENTUCKY · PI Michael Paul Murphy, LINDA J VAN ELDIK · 2022 to 2026
$2.3M
UKNeu-PREP: University of Kentucky Neuroscience Postbaccalaureate Research Education ProgramR25NS130963 · NINDS · UNIVERSITY OF KENTUCKY · PI BRADLEY, LUKE H, GENSEL, JOHN C · 2023 to 2025
$1.1M
NIA NIH HHS R01 AG068215NIA NIH HHS T32 AG078110NINDS NIH HHS R25 NS130963
6 · The paper itself

Abstract

Artificial light at night (light pollution) is widespread but understudied in the context of Alzheimer's disease (AD). Sleep and circadian disruption have been linked to amyloid-β (Aβ) accumulation and neuroinflammation, but whether dim light at night (dLAN) modifies these processes remains unclear. We tested whether chronic dLAN exposure (8 lux during the dark phase, 8 weeks) alters circadian rhythms, amyloid pathology, and neuroinflammation in 12-13 month-old humanized APP knock-in (KI) mice. hAPP

Indexed as

Alzheimer’s diseaseamyloid-βastrocytescircadian rhythmsdim light at night (dLAN)light pollutionmicroglianeuroinflammation

Identifiers

PMID41256678
PMCPMC12622053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.