Evidence map›Paper›PMID 41256674›Full record

ArticlebioRxiv : the preprint server for biology2025

Hemidesmosomes regulate epidermal differentiation during embryogenesis.

Juliet S King, Kendall J Lough, Scott E Williams

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Juliet S KingUniversity of North Carolina at Chapel Hill.ORCID 0000-0003-3865-6956
Kendall J LoughUniversity of North Carolina at Chapel Hill.ORCID 0000-0001-9663-6983
Scott E WilliamsPathology/UNC Chapel Hill.ORCID 0000-0001-9975-7334

Funding

Intrinsic and extrinsic spindle orientation mechanisms in mammalian epidermisR01AR077591 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WILLIAMS, SCOTT E · 2021 to 2025
$1.6M
Training Program in Cellular Systems and Integrative PhysiologyT32GM133364 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Caron, Natasha T Snider · 2020 to 2026
$1.4M
Determining the role of cell-cell adhesions in palate closureF31DE033915 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Juliet Stanton King · 2024 to 2026
$84k
NIAMS NIH HHS R01 AR077591NIDCR NIH HHS F31 DE033915NIGMS NIH HHS T32 GM133364
6 · The paper itself

Abstract

In skin epidermis, integrins mediate adhesion of basal keratinocytes to the underlying basement membrane. While high expression of integrins has been correlated with stemness, there is limited direct evidence that integrins mediate keratinocyte retention within the basal layer. Here, we generate mosaic, epidermal-specific loss of integrin-β4 (encoded by

Identifiers

PMID41256674
PMCPMC12621979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.