Evidence map›Paper›PMID 41256671›Full record

ArticlebioRxiv : the preprint server for biology2025

Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer.

Lee J Pribyl, Jennifer E Kay, Joshua J Corrigan, Lindsay B Volk, Monét Norales, Norah A Owiti, Evan A Kowal, Ishwar N Kohale, Ilana S Nazari, Matilda R Swanson and 14 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Lee J PribylDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0003-0209-7814
Jennifer E KaySilent Spring Institute, Newton, MA, 02460, USA.ORCID 0000-0001-5891-0689
Joshua J CorriganDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0009-0006-6252-4960
Lindsay B VolkDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0001-8472-3836
Monét NoralesDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Norah A OwitiDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0002-5061-7434
Evan A KowalDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Ishwar N KohaleDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0001-8225-1740
Ilana S NazariDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0003-3074-9488
Matilda R SwansonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0009-0004-0769-5543
Aimee C MoiseDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0003-4927-5972
Duanduan MaDavid H. Koch Institute for Integrative Cancer Research, Bioinformatics and Computing Facility of Swanson Biotechnology Center, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0002-4753-0813
Stuart S LevineBioMicro Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0001-7363-562X
Emily MichelsenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0009-0008-1667-1067
Robert G CroyDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0002-3498-3311
Timothy RaganTissueVision, Newton, MA, 02458, USA.ORCID 0000-0001-6300-0858
Dorothea K TorousLitron Laboratories, Rochester, NY, 14623, USA.
Svetlana L AvlasevichLitron Laboratories, Rochester, NY, 14623, USA.
Stephen D DertingerLitron Laboratories, Rochester, NY, 14623, USA.
Sebastian E CarrascoLaboratory of Comparative Pathology, Weill Cornell Medicine, Memorial Sloan Kettering Cancer Center and Rockefeller University, New York, NY, 10065, USA.
Leona D SamsonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
John M EssigmannDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0002-2196-5691
Forest M WhiteDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0002-1545-1651
Bevin P EngelwardDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.ORCID 0000-0003-4322-3573

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
The MIT Superfund Research Program: A Systems Approach for the Protection of Human Health from Hazardous ChemicalsP42ES027707 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Stuart S Levine · 2017 to 2026
$22.2M
TRAINING GRANTS IN ENVIROMENTAL TOXICOLOGYT32ES007020 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ESSIGMANN, JOHN M · 1985 to 2024
$13.1M
NIEHS NIH HHS P30 ES002109NIEHS NIH HHS P42 ES027707NIEHS NIH HHS T32 ES007020
6 · The paper itself

Abstract

N-Nitrosodimethylamine (NDMA), a probable human carcinogen, induces toxic and mutagenic

Identifiers

PMID41256671
PMCPMC12621704

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.