Evidence map›Paper›PMID 41256669›Full record

ArticlebioRxiv : the preprint server for biology2025

Synthetic collinearization of a chromosome segment enables genetic dissection of incompatibility between distant genera.

Shawn H Yang, Alessandro L V Coradini, Cara B Hull, Daniel T Lusk, Ian M Ehrenreich

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shawn H YangMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0000-5943-0548
Alessandro L V CoradiniMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-7923-9994
Cara B HullMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-7683-3613
Daniel T LuskMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Ian M EhrenreichMolecular and Computational Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-5065-9063

Funding

Characterizing the complex underpinnings of genetic background effectsR35GM130381 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Ian Michael Ehrenreich · 2019 to 2026
$3.3M
Genetics of fungal persistence and pathogenicity in mammalian hostsR56AI171091 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EHRENREICH, IAN MICHAEL · 2023 to 2023
$624k
NIAID NIH HHS R56 AI171091NIGMS NIH HHS R35 GM130381
6 · The paper itself

Abstract

Reproductive barriers and genomic structural differences hinder genetic analysis between highly divergent organisms. Here, we examined whether these challenges can be overcome by collinearization, the synthesis of chromosomes that retain the native gene content and organization of a host organism while incorporating the DNA sequences of another organism. We applied collinearization to

Identifiers

PMID41256669
PMCPMC12621872

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.