Evidence map›Paper›PMID 41256667›Full record

ArticlebioRxiv : the preprint server for biology2025

Human brain organoids record the passage of time over multiple years in culture.

Irene Faravelli, Noelia Antón-Bolaños, Anqi Wei, Tyler Faits, Abhishek Sampath Kumar, Sophia Andreadis, Rahel Kastli, Marta Montero Crespo, Mara Steiger, Daniel Leible and 14 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Novel advanced patient-derivedFrontiers in neurology
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Noelia Antón-BolañosORCID 0000-0001-6590-4316
Anqi Wei
Tyler Faits
Abhishek Sampath Kumar
Sophia Andreadis
Rahel Kastli
Marta Montero Crespo
Mara Steiger
Daniel Leible
Elizabeth Zhang
Bobae An
Yaron Meirovitch
Sayara Silwal
Sung Min Yang
Alexander Kovacsovics
Xian Adiconis
Helene Kretzmer
Edward S Boyden
Jeff Lichtman
Aviv Regev
Alexander Meissner
Paola Arlotta

Funding

Modeling ASD-linked genetic mutations in 3D human brain organoidsR01MH112940 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta · 2018 to 2026
$5.2M
NIMH NIH HHS R01 MH112940
6 · The paper itself

Abstract

The human brain develops and matures over an exceptionally prolonged period of time that spans nearly two decades of life. Processes that govern species-specific aspects of human postnatal brain development are difficult to study in animal models. While human brain organoids offer a promising

Identifiers

PMID41256667
PMCPMC12622013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.