Evidence map›Paper›PMID 41256658›Full record

ArticlebioRxiv : the preprint server for biology2025

Divergent Pathways of Surfactant Protein C Maturation for Disease-Associated Isoforms.

Sarah Bui, Anamarie Reineberg, Dakota Jones, Cheng-Lun Na, Joseph Kitzmiller, Luis R Rodriguez, Aditi Murthy, Swati Iyer, Charlotte Cooper, Rea Chroneos and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Sarah BuiPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Anamarie ReinebergPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Dakota JonesCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Cheng-Lun NaPerinatal Institute and Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center. Cincinnati OH 45221 USA.
Joseph KitzmillerPerinatal Institute and Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center. Cincinnati OH 45221 USA.
Luis R RodriguezPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.ORCID 0000-0001-7176-0697
Aditi MurthyPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Swati IyerPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Charlotte CooperPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Rea ChroneosPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Yaniv TomerPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Surafel MulugetaPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.
Timothy E WeaverPerinatal Institute and Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center. Cincinnati OH 45221 USA.
Darrell N KottonCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Konstantinos-Dionysios AlysandratosCenter for Regenerative Medicine, Boston University and Boston Medical Center, Boston, MA 02118, USA.
Jeffrey A WhitsettPerinatal Institute and Division of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center. Cincinnati OH 45221 USA.ORCID 0000-0003-1668-5174
Michael F BeersPulmonary and Critical Care Division, Department of Medicine; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA 19104.ORCID 0000-0002-2149-3209

Funding

Patient-specific iPSCs to model and treat the inception of pulmonary fibrosisP01HL170952 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2024 to 2026
$11.4M
Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3M
Epithelial stem/progenitor cells as repair agents in diffuse alveolar damageU01HL134766 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAPMAN, HAROLD A, KOTTON, DARRELL N. · 2016 to 2022
$8.1M
Derivation of Transplantable Lung Epithelial Progenitors from iPS CellsR01HL095993 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2009 to 2026
$7.5M
Research Center for Spatiotemporal Lung Imaging and OmicsU01HL148860 · NHLBI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI ADKINS, JOSHUA N., CARSON, JAMES PAUL · 2019 to 2023
$4.7M
Alveolar Epithelial Cell Dysfunction in Pulmonary Fibrosis: Leveraging SFTPC Mutations for Discovery of Molecular and Cellular TargetsR01HL145408 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MICHAEL FRANCIS BEERS · 2019 to 2026
$4.6M
Developing a patient-specific organoid model of pulmonary fibrosis using iPSCsU01HL152976 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N. · 2021 to 2024
$2.5M
Role of EMC3/TMEM111 in Alveolar Epithelial Cell FunctionR01HL136722 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LIN, XINHUA, WHITSETT, JEFFREY A · 2017 to 2020
$2.1M
Biosynthesis and Trafficking of Surfactant Protein C In Health and DiseaseR01HL119436 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BEERS, MICHAEL FRANCIS · 2013 to 2017
$2.0M
Generation of functional lung stem cells from human iPSCsU01HL148692 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Finn Hawkins, Darrell N. Kotton · 2019 to 2026
$2.0M
Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosisK08HL163494 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Konstantinos Alysandratos · 2023 to 2026
$649k
Aging and Metabolic Dysfunction Drive Disrupted Alveolar Epithelial Progenitor Function in Pulmonary FibrosisK99HL171946 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI RODRIGUEZ, LUIS R · 2024 to 2024
$163k
BLRD VA I01 BX001176NHLBI NIH HHS F32 HL160011NHLBI NIH HHS K08 HL163494NHLBI NIH HHS K99 HL171946NHLBI NIH HHS P01 HL170952NHLBI NIH HHS R01 HL095993NHLBI NIH HHS R01 HL119436NHLBI NIH HHS R01 HL136722NHLBI NIH HHS R01 HL145408NHLBI NIH HHS U01 HL134745NHLBI NIH HHS U01 HL134766NHLBI NIH HHS U01 HL148692NHLBI NIH HHS U01 HL148860NHLBI NIH HHS U01 HL152976
6 · The paper itself

Abstract

Surfactant Protein C (SP-C), a hydrophobic protein exclusively synthesized and secreted by alveolar type II (AT2) cells, is important for reducing alveolar surface tension in the distal lung. Chronic interstitial pulmonary diseases have been associated with

Indexed as

Alveolar Type 2 CellGolgiProprotein ConvertaseProtein MaturationSurfactant Protein C

Identifiers

PMID41256658
PMCPMC12621905

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.