Evidence map›Paper›PMID 41256604›Full record

ArticlebioRxiv : the preprint server for biology2025

Whole-chromosome duplications drive antimicrobial resistance in

Anna E Lehmann, Enrique Aguilar Ramírez, Nancy P Keller, Joseph Heitman

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Anna E LehmannDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0009-0004-8544-9292
Enrique Aguilar RamírezDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0001-7367-7846
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI, USA.ORCID 0000-0002-4386-9473
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-6369-5995

Funding

RNAi-dependent epimutation roles in antimicrobial drug resistance and pathogenesisR01AI170543 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2022 to 2026
$3.6M
Calcineurin signaling cascades governing Cryptococcus virulenceR01AI172451 · NIAID · DUKE UNIVERSITY · PI JOSEPH HEITMAN · 2023 to 2026
$2.7M
Accessing the hidden biosynthetic capabilities of fungiR35GM156119 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI NANCY P KELLER · 2025 to 2026
$923k
NIAID NIH HHS R01 AI170543NIAID NIH HHS R01 AI172451NIGMS NIH HHS R35 GM156119
6 · The paper itself

Abstract

Aneuploidy causes genome plasticity and enables adaptive responses that confer drug resistance in eukaryotes ranging from fungal pathogens to human cancer cells.

Indexed as

aneuploidyantimicrobial resistanceAspergillus fumigatussecondary metabolism

Identifiers

PMID41256604
PMCPMC12621686

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.