ArticlebioRxiv : the preprint server for biology2025
Mechanisms of Differential Signal Transduction by IFNLR1 Variants.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Lambda interferons bind the interferon lambda receptor-1 (IFNLR1) and IL10RB heterodimer to induce interferon stimulated genes (ISGs) and impart antiviral immunity. We previously showed that protein variants derived from distinct Methods: We used HEK293T cells, wild-type (WT), and Results: While each IFNLR1 variant colocalized with IL10RB after IFNL treatment, variant 1 was more rapidly and extensively internalized than variant 2. In WT iHeps with intact endogenous Conclusions: IFNLR1 variants promote differential utilization of signaling mediators to influence IFNL-induced gene expression patterns, indicating a putative role in pathway regulation.
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