Evidence map›Paper›PMID 41256566›Full record

ArticlebioRxiv : the preprint server for biology2025

PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function.

Babli Adhikary, Alexander Chang, Atsuko Y Higashi, Hideki Chiba, Ann L Miller, Tomohito Higashi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Babli AdhikaryDepartment of Molecular, Cellular, and Developmental Biology (MCDB), University of Michigan, Ann Arbor, MI 48109-1085, USA.ORCID 0009-0007-0573-1426
Alexander ChangDepartment of Molecular, Cellular, and Developmental Biology (MCDB), University of Michigan, Ann Arbor, MI 48109-1085, USA.
Atsuko Y HigashiDepartment of Nephrology and Hypertension, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0009-0005-3300-0597
Hideki ChibaDepartment of Basic Pathology, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0003-1777-8460
Ann L MillerDepartment of Molecular, Cellular, and Developmental Biology (MCDB), University of Michigan, Ann Arbor, MI 48109-1085, USA.ORCID 0000-0002-7293-764X
Tomohito HigashiDepartment of Basic Pathology, Fukushima Medical University, Fukushima 960-1295, Japan.ORCID 0000-0001-5616-1477

Funding

UG Diversity Supplement: Epithelial cell-cell junction remodeling in response to cell- and tissue-scale forcesR35GM153204 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ann Louise Miller · 2024 to 2026
$1.0M
NIGMS NIH HHS R35 GM153204
6 · The paper itself

Abstract

Cell-cell junctions are essential for epithelial integrity and barrier function, but the mechanisms regulating their remodeling remain unclear. Here, we investigated the role of the junctional kinase PAK4 in vertex remodeling. PAK4 localized to apical junctions and accumulated at multicellular vertices in MCDK cells and

Identifiers

PMID41256566
PMCPMC12621967

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.