Evidence map›Paper›PMID 41256556›Full record

ArticlebioRxiv : the preprint server for biology2025

The tetraspanin disc proteins, peripherin-2 and ROM1, facilitate CNG channel localization to the rod outer segment.

Molly T Thorson, Stephanie E Wei, Junseo Park, Jorge Y Martínez-Márquez, David G Ball, Jason R Willer, William J Spencer, Jillian N Pearring

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Stephanie E Wei
Junseo Park
Jorge Y Martínez-MárquezORCID 0000-0003-1485-4800
David G Ball
William J SpencerORCID 0000-0001-9301-3828
Jillian N PearringORCID 0000-0002-5352-2852

Funding

Understanding Photoreceptor Trafficking Pathways to the Outer SegmentR01EY032491 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jillian Nydam Pearring · 2022 to 2026
$2.2M
Training Program in Molecular and Translational Visual SciencesT32EY037212 · NEI · UPSTATE MEDICAL UNIVERSITY · PI WILLIAM J BRUNKEN · 2025 to 2026
$439k
Understanding the Role of GARP Proteins in Rod Outer Segment Disc Formation and Retinal DegenerationF32EY034760 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NAYLOR, MOLLY · 2023 to 2025
$242k
NEI NIH HHS F32 EY034760NEI NIH HHS R01 EY032491NEI NIH HHS T32 EY037212
6 · The paper itself

Abstract

The light-responsive outer segment of rod photoreceptors is composed of two distinct membrane subdomains: discs and the plasma membrane that surrounds them. To understand how proteins are delivered to these subdomains, we focused on the plasma membrane-specific cyclic nucleotide-gated (CNG) channel. It was previously reported that the β1 subunit of the CNG channel is absent from rods in peripherin-2 knockout (

Identifiers

PMID41256556
PMCPMC12621804

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.