Evidence map›Paper›PMID 41256545›Full record

ArticlebioRxiv : the preprint server for biology2025

Virally encoded interleukin-6 (vIL-6) coordinates with human IL-6 to modulate cytokine expression during KSHV infection.

Yahaira Bermudez, Samantha Schultz, Jacob Miles, Will Dwyer, Mandy Muller

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yahaira BermudezDepartment of Microbiology, University of Massachusetts, Amherst, USA.
Samantha SchultzDepartment of Microbiology, University of Massachusetts, Amherst, USA.
Jacob MilesDepartment of Microbiology, University of Massachusetts, Amherst, USA.
Will DwyerDepartment of Microbiology, University of Massachusetts, Amherst, USA.
Mandy MullerInstitute of Microbiology, University Hospital of Lausanne, University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-0056-3589

Funding

Chemistry-Biology Interface Predoctoral Training GrantT32GM139789 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ERIC Robert STRIETER · 2021 to 2026
$3.4M
RNA Modifications and Turnover during Viral-induced DecayR35GM138043 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI MULLER, MANDY · 2020 to 2024
$2.0M
NIGMS NIH HHS R35 GM138043NIGMS NIH HHS T32 GM139789
6 · The paper itself

Abstract

Kaposi Sarcoma-Associated Herpesvirus (KSHV) is characterized by its ability to establish lifelong infections that can lead to disease in immunocompromised individuals. Understanding the complex interactions between KSHV, the host cellular machinery, and the immune response is essential for unraveling the mechanisms underlying viral persistence and pathogenesis. KSHV extensively remodels the host gene expression landscape by inducing widespread RNA decay

Identifiers

PMID41256545
PMCPMC12621957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.