ArticlebioRxiv : the preprint server for biology2025
Hepatic ceramide synthesis links systemic inflammation to organelle dysfunction in cancer.
Ying Liu, Ting Miao, Alice Wang, Ezequiel Dantas, Ah-Ram Kim, Zhongjie Zhang, Xiaomei Sun, Richard Binari, John M Asara, Yanhui Hu and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Ying LiuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Ting MiaoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0634-7377 Alice WangCold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724 USA.
Ezequiel DantasDepartment of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.
Ah-Ram KimDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-9597-6759 Zhongjie ZhangDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Xiaomei SunDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Richard BinariDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-6155-9607 John M AsaraDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Yanhui HuDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1494-1402 Marcus D GoncalvesDepartment of Medicine, New York University Grossman School of Medicine, New York, NY 10016, USA.ORCID 0000-0002-0784-9248 Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7542-472X Funding
Characterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2MInvestigating metabolic responses to high sugar diets and the onset of diabetic phenotypesR01DK136945 · NIDDK · TRUSTEES OF INDIANA UNIVERSITY · PI Angelo D'Alessandro, NORBERT PERRIMON · 2023 to 2026
$2.4MCANCAN ? CORNELLOT2CA278685 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GONCALVES, MARCUS DASILVA · 2022 to 2023
$657kNCI NIH HHS OT2 CA278685NIAMS NIH HHS R01 AR057352NIDDK NIH HHS R01 DK136945
6 · The paper itselfAbstract
Paraneoplastic syndromes arise when tumor-derived cytokines reprogram distant organs. Although mediators such as Interleukin-6 have been implicated, how these signals impair host organ function remains incompletely defined. Here, we identify a cytokine-lipid axis that drives hepatic autophagy dysfunction. Specifically, in
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PMID41256541
PMCPMC12621733
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