Evidence map›Paper›PMID 41256507›Full record

ArticlebioRxiv : the preprint server for biology2025

T Cells Tear Apart Confining Extracellular Matrix Via a Breaststroke-like Motion to Generate Migration Paths.

Byunghang Ha, Peter Xie, Benjamin Johns, Cole Allan, Maria Korah, Daniel Delitto, Paul Bollyky, Natalie Torok, Ovijit Chaudhuri

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Byunghang HaDepartment of Mechanical Engineering, Stanford University, Stanford CA, 94305, USA.ORCID 0000-0002-4491-4627
Peter XieDepartment of Mechanical Engineering, Stanford University, Stanford CA, 94305, USA.
Benjamin JohnsDepartment of Mechanical Engineering, Stanford University, Stanford CA, 94305, USA.
Cole AllanDepartment of Mechanical Engineering, Stanford University, Stanford CA, 94305, USA.
Maria KorahDepartment of Surgery, Stanford University, Stanford CA, 94305, USA.
Daniel DelittoDepartment of Surgery, Stanford University, Stanford CA, 94305, USA.
Paul BollykyDepartment of Infectious Diseases, Stanford University, Stanford CA, 94305, USA.
Natalie TorokDepartment of Gastroenterology and Hepatology, Stanford University, Stanford CA, 94305, USA.
Ovijit ChaudhuriDepartment of Mechanical Engineering, Stanford University, Stanford CA, 94305, USA.ORCID 0000-0002-9287-3401

Funding

TRAINING GRANT IN ACADEMIC GASTROENTEROLOGYT32DK007056 · NIDDK · STANFORD UNIVERSITY · PI Natalie J. Torok · 1986 to 2026
$6.5M
Implementation of Decision Support for the Management of Obesity in a National Pediatric Primary Care Research NetworkR01MD014853 · NIMHD · YALE UNIVERSITY · PI SHARIFI, MAHNOOSH · 2020 to 2024
$3.9M
Role of extracellular matrix malleability in mediating breast cancer cell invasion and migrationR37CA214136 · NCI · STANFORD UNIVERSITY · PI CHAUDHURI, OVIJIT · 2018 to 2024
$2.5M
Matrix in pre-cirrhotic HCCR01CA277710 · NCI · STANFORD UNIVERSITY · PI Natalie J. Torok · 2023 to 2026
$2.3M
Regulation of Adherent Cell Proliferation by Matrix ViscoelasticityR01GM148535 · NIGMS · STANFORD UNIVERSITY · PI Ovijit Chaudhuri · 2023 to 2026
$1.5M
Tumor microenvironmental biomarkers of breast cancer invasionR01CA290021 · NCI · STANFORD UNIVERSITY · PI Ovijit Chaudhuri, Robert B West · 2025 to 2026
$1.3M
BLRD VA I01 BX002418NCI NIH HHS R01 CA277710NCI NIH HHS R01 CA290021NCI NIH HHS R37 CA214136NIDDK NIH HHS T32 DK007056NIGMS NIH HHS R01 GM148535NIMHD NIH HHS R01 MD014853
6 · The paper itself

Abstract

T cells migrate through soft tissues to target infected and abnormal cells and regulate immunity. T cell migration is typically studied in microfluidic devices or other contexts where there is a pre-existing migration path; how they create paths in confining nanoporous extracellular matrices (ECM), such as can occur during fibrosis and around tumors, remains unclear. Here, we studied T cell migration in confining collagen-rich matrices with a range of stiffness, viscoelasticity, mechanical plasticity, and shear strength, or the stress at which the material fails. Strikingly, only shear strength, the stress at which a material fails, not stiffness or viscoelasticity, correlates with migration. During migration, T-cells extend thin actin-rich, finger-like protrusions into the ECM, which then undergo a divergent breaststroke-like motion. Thus, T cells tear apart confining matrices using a breaststroke-like motion to generate migration paths.

Identifiers

PMID41256507
PMCPMC12622025

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.