Evidence map›Paper›PMID 41256487›Full record

ArticlebioRxiv : the preprint server for biology2025

Independent Associations of Sleep and Walking with Cognition in Parkinson's Disease: A Perivascular Spaces Analysis.

Francesca Sibilia, Giuseppe Barisano, Maryam Fotouhi, Philipp A Loehrer, Katherine Wong, Wendy J Mack, Mark F Lew, Haidar Dafsari, Jeiran Choupan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Francesca SibiliaLaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Giuseppe BarisanoDepartment of Neurosurgery, Stanford University, Stanford, 94305, CA.ORCID 0000-0001-5598-1369
Maryam FotouhiLaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Philipp A LoehrerDepartment of Neurology, Philipps-University Marburg, Marburg, Germany.
Katherine WongDepartment of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.
Wendy J MackDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90032, USA.ORCID 0000-0002-2474-7921
Mark F LewDepartment of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.
Haidar DafsariUniversity of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, 50937 Cologne, Germany.ORCID 0000-0001-8849-4233
Jeiran ChoupanLaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Funding

Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's diseaseR01AG070825 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOUPAN, JEIRAN · 2021 to 2025
$4.1M
NIA NIH HHS R01 AG070825
6 · The paper itself

Abstract

Perivascular spaces (PVSs) support brain waste clearance and are influenced by sleep. In Parkinson's disease (PD), sleep is often disrupted, and can co-occur with gait dysfunction. This study investigated how sleep disruption, walking difficulties, and cognition relate in PD, considering PVS as a mediator. Our cohort included 348 participants -healthy controls (HC, n=59), prodromal (n=117), and PD patients (n=172)- in the Parkinson's Progression Markers Initiative (PPMI) study. Insomnia and walking issues were assessed by questionnaire, cognition was measured with the Symbol Digit Modalities (SDM) test, and PVS volume fraction in white matter (WM-PVS) and basal ganglia (BG-PVS) was quantified. PVS did not mediate the relationship between sleep or motor problems, on cognition. Walking difficulties were directly linked to poorer cognition, and insomnia to walking deficits. BG-PVS was negatively associated with cognition. PVS burden predicted cognitive function after five years, but not disease progression as indexed by cerebro-spinal fluid (CSF) biomarkers. These findings suggest walking deficits directly relate with cognition in PD, but the relationship is not mediated by PVS.

Identifiers

PMID41256487
PMCPMC12622019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.