ArticlebioRxiv : the preprint server for biology2025
A validated set of neural gene reporter mice and chemical tracers tools for mapping knee innervating neurons.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Joint pain is an increasing concern for our aging population, as current therapies to slow joint disease progression or reduce pain are largely ineffective and often carry significant health and dependency risks. Age and joint disease induce changes to all tissues that make up the joint, including the dense neural network that innervates the joint. Several studies have correlated some joint innervation changes in joint diseases such as osteoarthritis or rheumatoid arthritis, but little is known about their respective functional consequences. In general, knee innervating neurons are classified as either non/peptidergic nociceptive or sympathetic neurons. How subtypes of these neurons affect the individual's pain experience remains relatively uncharacterized. The few studies typically focused on a single neural subtype due to the limited availability of validated tools to study joint innervation
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