Evidence map›Paper›PMID 41256460›Full record

ArticlebioRxiv : the preprint server for biology2025

Arid2 promotes Follicular B-cell differentiation and antibody responses

Rachel L Paolini, Sarah Zimmerman, Sadra Marjai, Sofia R Smith, Pei-Yu Chen, George P Souroullas

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rachel L PaoliniDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sarah ZimmermanDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sadra MarjaiDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sofia R SmithDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
Pei-Yu ChenDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.
George P SouroullasDepartment of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, Missouri, USA.

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
INSTITUTIONAL TRAINING GRANT IN GENOMIC SCIENCET32HG000045 · NHGRI · WASHINGTON UNIVERSITY · PI MICHAEL R BRENT, Barak A Cohen · 1997 to 2026
$8.4M
NCI NIH HHS P30 CA091842NHGRI NIH HHS T32 HG000045
6 · The paper itself

Abstract

SWI/SNF chromatin remodeling complexes regulate gene expression during development and differentiation. These complexes exist in distinct forms, including the polybromo-associated BAF (PBAF) complex, defined by the ARID2 subunit. ARID2 is frequently mutated in B cell leukemias, but its role in normal B cell development remains unknown. Using conditional knockout mice, we show that Arid2 deletion impairs B cell differentiation

Indexed as

antibody responsesARID2B cell developmentCD19-Crechromatin remodelingFollicular B cellsgerminal centerMb1-CrePBAFRNA-seqSWI/SNF

Identifiers

PMID41256460
PMCPMC12622011

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.