Evidence map›Paper›PMID 41256453›Full record

ArticlebioRxiv : the preprint server for biology2025

Metabolic STAMP for deciphering GPCR-regulated insulin secretion by pancreatic β cells.

Mohammad Ovais Aziz-Zanjani, Rachel E Turn, Yan Hang, Anushweta Asthana, Leilani Elizabeth LaBrie, Mohammadamin Mobedi, Lucy Artemis Xu, Michael Krawitzky, Seung K Kim, Peter K Jackson

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohammad Ovais Aziz-ZanjaniBaxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Rachel E TurnBaxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yan HangStanford Diabetes Research Center, Department of Developmental Biology, Stanford University School of Medicine, Stanford CA 94305, USA.
Anushweta AsthanaBaxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Leilani Elizabeth LaBrieBaxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Mohammadamin MobediBaxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lucy Artemis XuBaxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Michael KrawitzkyBruker Scientific, San Jose, CA, USA.
Seung K KimStanford Diabetes Research Center, Department of Developmental Biology, Stanford University School of Medicine, Stanford CA 94305, USA.
Peter K JacksonBaxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Funding

Stanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5M
Mechanisms of Ciliary Signaling Controlling Obesity and Metabolic DiseaseR01GM121565 · NIGMS · STANFORD UNIVERSITY · PI JACKSON, PETER KENT · 2017 to 2025
$4.3M
Therapeutic targeting of human islets with recombinant regulatory T cellsU01DK123743 · NIDDK · STANFORD UNIVERSITY · PI KIM, SEUNG K, MEYER, EVERETT · 2019 to 2022
$2.9M
In vivo systems to discover mechanisms regulating human islet alpha cell functionR01DK126482 · NIDDK · STANFORD UNIVERSITY · PI KIM, SEUNG K, MACDONALD, PATRICK · 2020 to 2023
$2.2M
Regulation of gastrointestinal hormone signaling and metabolism by Neuromedin UR01DK107507 · NIDDK · STANFORD UNIVERSITY · PI KIM, SEUNG K · 2017 to 2021
$2.0M
Discovering genetic and hormonal mechanisms underlying diabetes risk from flies to humansR01DK108817 · NIDDK · STANFORD UNIVERSITY · PI KIM, SEUNG K · 2018 to 2022
$2.0M
Centriolar-ciliary signaling mechanisms in tissue regeneration and differentiationR01GM114276 · NIGMS · STANFORD UNIVERSITY · PI JACKSON, PETER KENT · 2015 to 2018
$1.5M
TULP3 integrates essential ciliary functionsK99GM154060 · NIGMS · STANFORD UNIVERSITY · PI TURN, RACHEL ELIZABETH · 2024 to 2025
$250k
The Role of eIF4G1 and eIF4G2 in Translational Control of Adipogenesis and ObesityF32GM142180 · NIGMS · STANFORD UNIVERSITY · PI TURN, RACHEL ELIZABETH · 2022 to 2023
$137k
NIDDK NIH HHS P30 DK116074NIDDK NIH HHS R01 DK107507NIDDK NIH HHS R01 DK108817NIDDK NIH HHS R01 DK126482NIDDK NIH HHS U01 DK123743NIGMS NIH HHS F32 GM142180NIGMS NIH HHS K99 GM154060NIGMS NIH HHS R01 GM114276NIGMS NIH HHS R01 GM121565
6 · The paper itself

Abstract

Pancreatic β cells integrate glucose and metabolic cues to regulate insulin secretion, a process disrupted in T2D. GPCRs play a critical role in fine-tuning insulin release, yet the mechanisms by which ciliary (

Indexed as

acetylationATAT1ERKFFAR4 (Free Fatty Acid Receptor 4)GLP1-R (Glucagon-Like Peptide-1 Receptor)GPCRs (G protein-coupled receptors)GSIS (glucose-stimulated insulin secretion)HDAC6 (Histone De-Acetylase 6)inter-organellar contactsMetabolic-STAMP (Synchronized Temporal-Spatial Analysis via Microscopy and Phosphoproteomics)microtubulesMIN6 (mouse β-cell line)PKA (Protein Kinase A)primary human isletsPTMs (post-translational modifications)T2D (Type 2 Diabetes)

Identifiers

PMID41256453
PMCPMC12621840

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.