Evidence map›Paper›PMID 41256435›Full record

ArticlebioRxiv : the preprint server for biology2025

Electroencephalography, pupillometry, and behavioral evidence for locus coeruleus-noradrenaline system related tonic hyperactivity in older adults.

Andy Jeesu Kim, Santiago Morales, Joshua Senior, Mara Mather

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Andy Jeesu KimUniversity of Southern California.ORCID 0000-0003-1124-0213
Santiago MoralesUniversity of Southern California.
Joshua SeniorUniversity of Southern California.
Mara MatherUniversity of Southern California.

Funding

RESEARCH TRAINING IN GERONTOLOGYT32AG000037 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE, EILEEN M CRIMMINS · 1985 to 2026
$13.2M
Locus Coeruleus Imaging Markers in Preclinical Alzheimers disease, Cerebrovascular Disease and Cognitive DeclineR01AG082073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONDI, MARK W, MATHER, MARA · 2023 to 2025
$4.9M
Effects of Resonance-Frequency Breathing on Preclinical Alzheimer’s Disease Biomarkers and CognitionR01AG080652 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2023 to 2026
$3.9M
The effects of noradrenergic activity on age-related distractibilityF32AG076288 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIM, ANDY JEESU · 2022 to 2025
$164k
NIA NIH HHS F32 AG076288NIA NIH HHS R01 AG080652NIA NIH HHS R01 AG082073NIA NIH HHS T32 AG000037
6 · The paper itself

Abstract

Neuroimaging studies have shown that age-related dysregulation of the locus coeruleus-noradrenaline (LC-NA) system is associated with cognitive decline. However, due to limitations in directly measuring LC function

Indexed as

agingarousalelectroencephalographylocus coeruleuspupillometry

Identifiers

PMID41256435
PMCPMC12621999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.