Evidence map›Paper›PMID 41256432›Full record

ArticlebioRxiv : the preprint server for biology2025

De novo design of RNA and nucleoprotein complexes.

Andrew Favor, Riley Quijano, Elizaveta Chernova, Andrew Kubaney, Connor Weidle, Morgan A Esler, Lilian McHugh, Ann Carr, Yang Hsia, David Juergens and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Andrew FavorGraduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0002-9977-2785
Riley QuijanoDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.
Elizaveta ChernovaInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA.
Andrew KubaneyGraduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA.ORCID 0009-0009-4982-6050
Connor WeidleInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA.
Morgan A EslerDivision of Basic Sciences, Fred Hutchinson Cancer Center Seattle, WA, 98109 USA.
Lilian McHughDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.
Ann CarrDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.
Yang HsiaDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0001-7467-8373
David JuergensGraduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA.
Kenneth D CarrInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA.
Paul T KimGraduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA.
Yuliya PolitanskaDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.
Enisha SehgalGraduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA.
Paul S KwonDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.
Robert J PecoraroDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.
Cameron GlasscockDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.
Andrew J BorstInstitute for Protein Design, University of Washington, Seattle, WA 98105, USA.
Frank DiMaioDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.ORCID 0000-0002-7524-8938
Barry L StoddardDivision of Basic Sciences, Fred Hutchinson Cancer Center Seattle, WA, 98109 USA.
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98105, USA.

Funding

User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
Biophysical and structural studies of protein and enzyme mechanism, evolution, and engineeringR35GM148166 · NIGMS · FRED HUTCHINSON CANCER CENTER · PI BARRY L. STODDARD · 2023 to 2026
$2.3M
Acquisition of a Rigaku XtaLAB Synergy-R macromolecular diffraction instrumentation at Fred Hutchinson Cancer Research CenterS10OD028581 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STODDARD, BARRY L. · 2020 to 2020
$600k
NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R35 GM148166NIH HHS S10 OD028581
6 · The paper itself

Abstract

Nucleic acids fold into sequence-dependent tertiary structures and carry out diverse biological functions, much like proteins. However, while considerable advances have been made in the

Identifiers

PMID41256432
PMCPMC12621682

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.