Evidence map›Paper›PMID 41256420›Full record

ArticlebioRxiv : the preprint server for biology2025

Core Clock Protein Subcellular Dynamics Coordinate Local and Global Circadian Control in Syncytia.

Ziyan Wang, Bradley M Bartholomai, Bin Wang, David Ritz, Daniel Schultz, Jennifer J Loros, Jay C Dunlap

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ziyan WangDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0002-2642-6654
Bradley M BartholomaiDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0002-3082-3425
Bin WangDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0002-0068-2887
David RitzDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Daniel SchultzDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Jennifer J LorosDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Jay C DunlapDepartment of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Funding

Bioinformatics Resource Centers for Infectious Diseases: Tickborne Diseases Activities 75N93019C00077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROOS, DAVID · 2019 to 2023
$30.8M
Zhao - Proj 2P20GM130454 · NIGMS · DARTMOUTH COLLEGE · PI MICHAEL L WHITFIELD · 2019 to 2026
$27.2M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI HIGGS, HENRY N · 2016 to 2025
$25.9M
Genetic and Molecular Dissection of the Neurospora ClockR35GM118021 · NIGMS · DARTMOUTH COLLEGE · PI Jay C. Dunlap · 2016 to 2026
$7.3M
Super-resolution spinning disk confocal microscope for Dartmouth Life SciencesS10OD032310 · OD · DARTMOUTH COLLEGE · PI AHMED, YASMATH · 2022 to 2022
$600k
NIAID NIH HHS 75N93019C00077NIGMS NIH HHS P20 GM113132NIGMS NIH HHS P20 GM130454NIGMS NIH HHS R35 GM118021NIH HHS S10 OD032310
6 · The paper itself

Abstract

Circadian rhythms are pervasive among eukaryotes, and the underlying clocks share a common regulatory architecture - a negative feedback loop. A wealth of genetic and biochemical data underpin current perceptions of circadian oscillators but aspects of their cell biology remain cryptic, especially in syncytial systems. We employed novel microfluidic systems and a blind mutant that retains circadian function to simultaneously track multiple clock components

Identifiers

PMID41256420
PMCPMC12621684

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.