Evidence map›Paper›PMID 41256419›Full record

ArticlebioRxiv : the preprint server for biology2025

Progressive Loss of Astrocytic AIBP Expression during Alzheimer's Disease Pathology.

Shihui Ding, Soo-Ho Choi, Yi Sak Kim, Nicolaus Nazarenkov, Yury I Miller

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shihui DingDepartment of Medicine, University of California, San Diego, California, USA.
Soo-Ho ChoiDepartment of Medicine, University of California, San Diego, California, USA.ORCID 0000-0003-1152-1509
Yi Sak KimDepartment of Medicine, University of California, San Diego, California, USA.ORCID 0000-0003-4477-0018
Nicolaus NazarenkovDepartment of Medicine, University of California, San Diego, California, USA.
Yury I MillerDepartment of Medicine, University of California, San Diego, California, USA.ORCID 0000-0003-0521-7690

Funding

UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Steven Dyal Edland · 2019 to 2026
$34.9M
U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Reversing Microglial Inflammarafts and Mitochondrial Dysfunction in Alzheimer's DiseaseR01AG081037 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Mark H Ellisman, WONKYU JU · 2023 to 2026
$3.1M
AIBP-mediated neuroprotection in glaucomatous optic neuropathyR01EY034116 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SOO-HO CHOI, WONKYU JU · 2023 to 2026
$2.6M
Macrophage Inflammarafts and Mitochondrial Dysfunction in AtherosclerosisR01HL171505 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yury Miller · 2024 to 2026
$2.3M
Role of TLR4-lipid rafts in nociceptionR01NS132483 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Patrick M Dougherty, Yury Miller · 2024 to 2026
$2.3M
NEI NIH HHS R01 EY034116NHLBI NIH HHS R01 HL171505NIA NIH HHS P30 AG062429NIA NIH HHS R01 AG081037NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS132483
6 · The paper itself

Abstract

Astrocytes and microglia play crucial roles in mediating neuroinflammation during Alzheimer's disease (AD) progression. ApoA-I binding protein (APOA1BP, also known as AIBP/NAXE) attenuates neuroinflammation by blocking amyloid β-induced TLR4 inflammaraft formation and oxidative stress.

Indexed as

Alzheimer’s diseaseapolipoprotein A-I binding proteinastrocytesneuroinflammation

Identifiers

PMID41256419
PMCPMC12621687

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.