Evidence map›Paper›PMID 41256400›Full record

ArticlebioRxiv : the preprint server for biology2025

Missense variants in the myosin binding domains of

Kelly N Araujo, Hannah E Cizauskas, Yoldas Yildiz, Geena E Fritzmann, Tuan Bui, Lucas M Wittenkeller, Alexandra Peña, Toni R Pak, David Y Barefield

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kelly N AraujoDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.
Hannah E CizauskasDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.
Yoldas YildizDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.
Geena E FritzmannDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.
Tuan BuiDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.
Lucas M WittenkellerDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.
Alexandra PeñaDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.
Toni R PakDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.
David Y BarefieldDepartment of Cell and Molecular Physiology, Loyola University Chicago, 2160 S. 1st Ave, Maywood, IL, 60153, USA.ORCID 0000-0002-6166-640X

Funding

SPECIFIC REGULATION OF CARDIAC ATRIAL CONTRACTILITYR01HL181346 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI David Y Barefield · 2025 to 2026
$1.3M
Myofilament proteins in cardiomyopathy and arrhythmiasR00HL141698 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI BAREFIELD, DAVID Y · 2020 to 2022
$747k
Regulation of atrial contractility in cardiomyopathyR56HL165137 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI BAREFIELD, DAVID Y · 2022 to 2022
$597k
NHLBI NIH HHS R00 HL141698NHLBI NIH HHS R01 HL181346NHLBI NIH HHS R56 HL165137
6 · The paper itself

Abstract

Approximately 40% of genetic hypertrophic cardiomyopathy cases involve mutations in

Indexed as

AtriaCardiomyopathyMyBP-CMyBP-HLMyosin Binding Protein

Identifiers

PMID41256400
PMCPMC12622004

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.