Evidence map›Paper›PMID 41256397›Full record

ArticlebioRxiv : the preprint server for biology2025

Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain.

Meenakshi Chakraborty, Sophia M Shi, Imani E Porter, Daniel J Richard, Georgi K Marinov, Ashley A Moore, Jenna L E Blum, Aravind Natarajan, James W Jahng, Joseph C Wu and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Meenakshi ChakrabortyDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8985-7219
Sophia M ShiDepartment of Chemistry, Stanford University, Stanford, CA, USA.ORCID 0000-0001-6935-1034
Imani E PorterDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0043-2658
Daniel J RichardDepartment of Genetics, Stanford University, Stanford, CA, USA.
Georgi K MarinovDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1822-7273
Ashley A MooreDepartment of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA.
Jenna L E BlumDivision of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0009-0003-7019-9174
Aravind NatarajanDepartment of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA.ORCID 0000-0003-2180-7842
James W JahngStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2367-6567
Joseph C WuStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6068-8041
Sydney X LuDepartment of Medicine, Divisions of Hematology and Blood & Marrow Transplantation, Stanford University, Stanford, CA, USA.ORCID 0000-0002-2217-1674
Shawn M DavidsonDivision of Pulmonary and Critical Care Medicine, Department of Medicine, The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.ORCID 0000-0003-0701-5275
William J GreenleafDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1409-3095
Nay L SawStanford Behavioral and Functional Neuroscience Laboratory, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Mehrdad ShamlooStanford Behavioral and Functional Neuroscience Laboratory, Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0003-4404-1755
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4608-6845
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-5893-0831
Ami S BhattDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8099-2975

Funding

INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
Culture-free pathogen tracking in hospitalized patientsR01AI143757 · NIAID · STANFORD UNIVERSITY · PI BHATT, AMI SIDDHARTH · 2020 to 2023
$3.0M
Defining and perturbing gene regulatory dynamics in the developing human brainR01NS128028 · NINDS · STANFORD UNIVERSITY · PI William James Greenleaf · 2023 to 2026
$2.4M
Emerging novel mechanisms of antibiotic resistance in the prevalent foodborne pathogen, SalmonellaR01AI148623 · NIAID · STANFORD UNIVERSITY · PI BHATT, AMI SIDDHARTH · 2019 to 2023
$2.0M
Mining the microbiome for immunomodulatory microproteinsR01CA301727 · NCI · STANFORD UNIVERSITY · PI MICHAEL C BASSIK, Ami Siddharth Bhatt · 2025 to 2026
$1.3M
Animal Research Equipment, Digital Cages & Metabolic, Avoidance, Fear Conditioning, Place Preference, Self-Administration, Open Field, & Microdialysis Systems for Translational NeuroscienceS10OD030452 · OD · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2021 to 2021
$743k
NCI NIH HHS R01 CA301727NHGRI NIH HHS T32 HG000044NIAID NIH HHS R01 AI143757NIAID NIH HHS R01 AI148623NIH HHS S10 OD030452NINDS NIH HHS R01 NS128028
6 · The paper itself

Abstract

The gut microbiome generates diverse metabolites that can enter the bloodstream and alter host biology, including brain function. Hundreds of physiologically relevant, gut-brain signaling molecules likely exist; however, there has been no systematic, high-throughput effort to identify and validate them. Here, we integrate computational,

Identifiers

PMID41256397
PMCPMC12621679

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.