Evidence map›Paper›PMID 41256384›Full record

ArticlebioRxiv : the preprint server for biology2025

Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia.

Naidi Sun, Yu-Yo Sun, Rui Cao, Hong-Ru Chen, Yiming Wang, Elizabeth Fugate, Marchelle R Smucker, Yi-Min Kuo, P Ellen Grant, Diana M Lindquist and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Naidi SunDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.
Yu-Yo SunInstitute of BioPharmaceutical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan 80424, Taiwan.
Rui CaoDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Hong-Ru ChenDepartment of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Yiming WangDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
Elizabeth FugateDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Marchelle R SmuckerDepartment of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Yi-Min KuoDepartment of Anesthesiology, Taipei Veterans General Hospital; Department of Anesthesiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan 11217, Taiwan.
P Ellen GrantFetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-1005-4013
Diana M LindquistDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Chia-Yi KuanDepartment of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA.
Song HuDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130, USA.

Funding

Integrating TPM and PAM to examine the metabolic underpinning of neurovascular repair after strokeR01NS120481 · NINDS · WASHINGTON UNIVERSITY · PI HU, SONG, LEE, JIN-MOO · 2021 to 2025
$3.1M
CMRO2 and Uncoupling of Oxidative-Phosphorylation in Experimental HIER01NS125677 · NINDS · UNIVERSITY OF VIRGINIA · PI Song Hu, Chia-Yi Kuan · 2022 to 2026
$2.8M
Neutrophils and Monocytes in Pediatric Ischemic StrokeR01NS125788 · NINDS · UNIVERSITY OF VIRGINIA · PI Chia-Yi Kuan · 2022 to 2026
$2.1M
Photoacoustic Microscopy of the Awake Mouse BrainR01NS099261 · NINDS · WASHINGTON UNIVERSITY · PI HU, SONG · 2017 to 2021
$1.7M
Monocyte-Derived Microglia in Development and after Neonatal Brain InjuryR21HD109025 · NICHD · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2023 to 2024
$444k
Perivascular Fibroblast-Endothelium Interactions in Hypertension and Cerebral IschemiaR21NS127392 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2022 to 2023
$444k
NICHD NIH HHS R21 HD109025NINDS NIH HHS R01 NS099261NINDS NIH HHS R01 NS120481NINDS NIH HHS R01 NS125677NINDS NIH HHS R01 NS125788NINDS NIH HHS R21 NS127392
6 · The paper itself

Abstract

Hypoxia-ischemia (HI), which disrupts the oxygen supply-demand balance in the brain by impairing blood oxygen supply and the cerebral metabolic rate of oxygen (CMRO

Indexed as

cerebral oxygen metabolismmulti-parametric photoacoustic microscopyneonatal brain hypoxia-ischemiatherapeutic hypothermiauncoupling of oxidative phosphorylation

Identifiers

PMID41256384
PMCPMC12621700

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.