ArticlebioRxiv : the preprint server for biology2025
Comparative transcriptomics reveals shifts in cortical architecture at the metatherian/eutherian transition.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The neocortex, a layered structure unique to mammals, supports higher-order functions such as perception, learning, and decision-making. While its overall organization is broadly conserved, it remains unclear whether changes to the cell type-specific organization of the cortical column-the basic unit of cortical processing- occurred at the metatherian/eutherian split. To address this, we used single-nucleus RNA sequencing and spatial transcriptomics to compare gene expression, cell types, and laminar architecture in the primary visual cortex of a metatherian (
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