ArticlebioRxiv : the preprint server for biology2025
A conserved logic for the development of cortical layering in tetrapods.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The evolutionary origin of the cerebral cortex, a brain region typically defined by the presence of neuronal layers, remains elusive. While mammals and reptiles have a layered cortex, the amphibian pallium (dorsal telencephalon) is considered unlayered. Here, we identify distinct superficial- and deep-layer neurons in the salamander pallium. Like in mammals, these layers develop sequentially from multipotent radial glia and intermediate progenitor cells. Using lineage tracing and scRNA-seq, we reveal conserved principles of cortical development, including the temporal patterning of radial glia and the association of neuronal birthdate, molecular identity, and projection type. Our findings indicate that the mammalian cortex evolved from this ancestral developmental template through the inversion of the corticogenesis gradient, from outside-in to inside-out, and the diversification of neuronal differentiation programs.
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