Evidence map›Paper›PMID 41256360›Full record

ArticlebioRxiv : the preprint server for biology2025

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis.

Vasileios Chortis, Kleiton Silva Borges, Cong-Hui Yao, Claudio Ribeiro, Luis Fernando Nagano, Mesut Berber, Alessandro Prete, Lukáš Najdekr, Michail E Klontzas, Andris Jankevics and 27 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Vasileios ChortisDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Kleiton Silva BorgesDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Cong-Hui YaoDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Claudio RibeiroDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Luis Fernando NaganoDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Mesut BerberDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Alessandro PreteDepartment of Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Lukáš NajdekrPhenome Centre Birmingham, School of Biosciences, University of Birmingham, Birmingham, UK.
Michail E KlontzasArtificial Intelligence and Translational Imaging (ATI) Lab, Department of Radiology, School of Medicine, University of Crete, Heraklion, Greece.
Andris JankevicsPhenome Centre Birmingham, School of Biosciences, University of Birmingham, Birmingham, UK.
Pedro VendraminiDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Jean Lucas KremerDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Liam KelleyDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Sathuwarman RaveenthirarajDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA.
Stylianos TsagarakisDepartment of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece.
Magdalena MacechDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Ivana D PupovacDepartment of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia.
Thomas G PapathomasDepartment of Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Betul HaykirDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.
Catherine WinderPhenome Centre Birmingham, School of Biosciences, University of Birmingham, Birmingham, UK.
Marcus QuinklerEndocrinology in Charlottenburg, Berlin, Germany.
M Conall DennedyDepartment of Medicine, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin, Republic of Ireland.
Grethe Å UelandDepartment of Medicine, section of Endocrinology, Haukeland University Hospital, Bergen, Norway.
Felix BeuschleinKlinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitäts-Spital Zürich (USZ) und Universität Zürich (UZH), Zurich, Switzerland.
Antoine TabarinService d'Endocrinologie, Centre Hospitalier Universitaire, Hopital du Haut Leveque, Pessac, France.
Martin FassnachtDepartment of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.ORCID 0000-0001-6170-6398
Angela E TaylorDepartment of Metabolism and Systems Science, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK.
Darko KastelanDepartment of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia.
Urszula AmbroziakDepartment of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Dimitra A VassiliadiDepartment of Endocrinology, Diabetes and Metabolism, Evangelismos Hospital, Athens, Greece.
Katja Kiseljak-VassiliadesRocky Mountain Regional Veterans Affairs Medical Center, Aurora, CO 80045, USA.
Irina BancosDivision of Endocrinology, Metabolism, Diabetes and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Diana L CarloneDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6935-0189
Warwick B DunnPhenome Centre Birmingham, School of Biosciences, University of Birmingham, Birmingham, UK.
Wiebke ArltMedical Research Council Laboratory of Medical Sciences, London, UK.
Marcia C HaigisDepartment of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
David T BreaultDivision of Endocrinology, Boston Children's Hospital, Boston, MA, USA.

Funding

Rosettes in Adrenal Development, Maintenance and DiseaseR01DK123694 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI David T Breault · 2019 to 2026
$5.6M
NIDDK NIH HHS R01 DK123694Wellcome Trust
6 · The paper itself

Abstract

Dysregulation of cellular metabolism is a hallmark of cancer, which remains poorly understood in adrenocortical carcinoma (ACC). Here, we dissected ACC metabolism by integrating transcriptional profiling from human and mouse ACC, targeted tissue metabolomics from a mouse ACC model, and untargeted serum metabolomics from a large patient cohort, providing cross-species validation of metabolic rewiring in ACC. This study revealed global metabolic dysregulation, involving glutamine-dependent pathways such as non-essential amino-acid and hexosamine biosynthesis, nucleotide metabolism, and glutathione biosynthesis, suggesting glutamine catabolism is a critical metabolic vulnerability in ACC. Treatment with glutamine antagonists 6-Diazo-5-Oxo-L-Norleucine (DON) and JHU-083 elicited robust anti-tumor responses. Mechanistic studies revealed DON's anti-tumor effect was primarily driven by selective inhibition of glutamine-fueled

Identifiers

PMID41256360
PMCPMC12621870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.