ArticleFrontiers in oncology2025
Case Report: Two cases of immune-associated myocarditis caused by tislelizumab.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The current phase of immune checkpoint inhibitors has improved the clinical outcomes of many cancer therapies; however, these agents may also lead to some high-consequence immune-related adverse events. We report two cases of cancer patients treated with tislelizumab, one with liver metastases after surgery for rectal cancer and one with non-small cell lung cancer. In both cases, elevated cardiac enzyme markers were observed, and one developed fatal myocarditis, while the other was treated with high-dose methylprednisolone steroid therapy and eventually improved. The probability of immune-associated myocarditis has been reported to be only 0.39%, but once myocarditis occurs, the mortality rate is more than 50%, making it a rare but serious side effect. Here, we discuss the antitumor treatment, the mechanism of immune-associated myocarditis induced by tislelizumab, the evaluation of the association, and the treatment after the development of immune-associated myocarditis in two patients, with the aim of improving clinical awareness of tislelizumab-induced immune-associated myocarditis and promoting timely judgment and appropriate therapeutic measures.
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