Evidence map›Paper›PMID 41256302›Full record

ArticleWorld journal of gastrointestinal endoscopy2025

Endoscopic biliary drainage with multi-hole self-expandable metallic stent during neoadjuvant chemoradiotherapy in pancreatic cancer.

Shohei Asada, Koh Kitagawa, Junichi Hanatani, Yuki Motokawa, Yui Osaki, Tomihiro Iwata, Kosuke Kaji, Akira Mitoro, Minako Nagai, Hitoshi Yoshiji and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shohei AsadaDepartment of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Koh KitagawaDepartment of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan. kitagawa@naramed-u.ac.jp.
Junichi HanataniDepartment of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Yuki MotokawaDepartment of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Yui OsakiDepartment of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Tomihiro IwataDepartment of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Kosuke KajiDepartment of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Akira MitoroDivision of Endoscopy, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Minako NagaiDepartment of Surgery, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Hitoshi YoshijiDepartment of Gastroenterology, Nara Medical University, Kashihara 634-8522, Nara, Japan.
Masayuki ShoDepartment of Surgery, Nara Medical University, Kashihara 634-8522, Nara, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeoadjuvant therapy (NAT) for pancreatic cancer (PC) is becoming standardized, with neoadjuvant chemoradiotherapy (NACRT) showing proven effectiveness. However, the optimal endoscopic biliary drainage approach during NAT remains controversial. In this single-center retrospective case series, we report the use of a novel multi-hole self-expandable metallic stent (MH-SEMS) for preoperative biliary drainage during NACRT in patients with PC.

aimTo assess the feasibility of endoscopic biliary drainage using MH-SEMS during NACRT in patients with malignant distal biliary obstruction secondary to resectable and borderline resectable PC.

methodsWe included 14 patients-10 with resectable, 2 with borderline resectable, and 2 with unresectable locally advanced disease-who had undergone surgery after biliary drainage using MH-SEMS (diameter: 10 mm). Clinical and technical success was achieved in all patients, with a median interval of 105 days between stent placement and surgery.

resultsA partial response was observed in five patients (35.7%), whereas nine patients (64.3%) exhibited stable disease. Only one patient (7.1%) developed moderate cholangitis from recurrent biliary obstruction caused by sludge 337 days after stent placement during systemic chemotherapy, requiring MH-SEMS replacement. Pathological examination of postoperative specimens revealed tumor shrinkage in many cases, and no stent migration was observed. Adverse events included mild pancreatitis in two patients (14.3%) and moderate pancreatitis in one patient (7.1%), as defined by the Tokyo Criteria 2024.

conclusionNo cases of cholecystitis, liver abscess, or hemorrhage were reported. No disadvantages in surgical procedures or postoperative complications related to MH-SEMS placement were observed.

Indexed as

Malignant biliary obstructionMulti-hole self-expandable metallic stentNeoadjuvant chemoradiotherapyNeoadjuvant therapyPancreatic cancer

Identifiers

PMID41256302
PMCPMC12620876

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.