Evidence map›Paper›PMID 41256240›Full record

ArticleBeilstein journal of organic chemistry2025

Palladium-catalyzed regioselective C1-selective nitration of carbazoles.

Vikash Kumar, Jyothis Dharaniyedath, Aiswarya T P, Sk Ariyan, Chitrothu Venkatesh, Parthasarathy Gandeepan

Abstract read
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Article in Beilstein journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Vikash KumarDepartment of Chemistry, Indian Institute of Technology Tirupati, Yerpedu- Venkatagiri Road, Yerpedu Post, Tirupati District, Andhra Pradesh 517619, India.
Jyothis DharaniyedathDepartment of Chemistry, Indian Institute of Technology Tirupati, Yerpedu- Venkatagiri Road, Yerpedu Post, Tirupati District, Andhra Pradesh 517619, India.
Aiswarya T PDepartment of Chemistry, Indian Institute of Technology Tirupati, Yerpedu- Venkatagiri Road, Yerpedu Post, Tirupati District, Andhra Pradesh 517619, India.ORCID https://orcid.org/0009-0009-1370-9960
Sk AriyanDepartment of Chemistry, Indian Institute of Technology Tirupati, Yerpedu- Venkatagiri Road, Yerpedu Post, Tirupati District, Andhra Pradesh 517619, India.
Chitrothu VenkateshDepartment of Chemistry, Indian Institute of Technology Tirupati, Yerpedu- Venkatagiri Road, Yerpedu Post, Tirupati District, Andhra Pradesh 517619, India.
Parthasarathy GandeepanDepartment of Chemistry, Indian Institute of Technology Tirupati, Yerpedu- Venkatagiri Road, Yerpedu Post, Tirupati District, Andhra Pradesh 517619, India.ORCID https://orcid.org/0000-0002-2483-7353

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbazoles are ubiquitous and privileged heterocyclic scaffolds in various functional organic materials and naturally occurring products. Although extensive efforts have focused on developing synthetic strategies toward carbazole derivatives, direct regioselective functionalization of the carbazole core remains challenging due to the inherently higher reactivity at the C3/C6 positions. In this study, we report a palladium-catalyzed, directing group-assisted, regioselective C1-H nitration of carbazoles. The protocol features a removable directing group and is amenable to gram-scale synthesis. This strategy provides a valuable platform for the selective functionalization of carbazoles, offering potential applications in optoelectronics, functional organic materials, and related areas while contributing to the advancement of C-H activation methodologies.

Indexed as

carbazolecatalysisC–H activationnitrationpalladium

Identifiers

PMID41256240
PMCPMC12621620

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.