ArticleSmall science2025
Janus Hydrogel Microparticles with Tea Polyphenol/Melanin Nanoparticles Integration from Microfluidics for Wound Healing.
Article in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Microfluidic Electrospray Microcapsules With Spatiotemporal Release of Asiatic Acid and Baicalein Nanocarriers for Wound Healing.Smart medicine · 2026Article
- Microfluidics, 3D bioprinted scaffold and organ-on-chip with biosensing activated therapeutic strategies for diabetic wound healing.Frontiers in bioengineering and biotechnology · 2026Review
- Janus Hydrogel Microparticles with Tea Polyphenol/Melanin Nanoparticles Integration from Microfluidics for Wound Healing.Small science · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Massive bioactives show outstanding performance in promoting wound healing, while their combined application remains challenging in avoiding mutual interference. Herein, Janus hydrogel microparticles co-loaded with tea polyphenol-magnesium and melanin nanoparticles for synergistically antioxidant and antibacterial wound treatment are proposed. The tea polyphenol-magnesium nanoparticles are prepared by the self-assembly of tea polyphenol molecule and magnesium ion, while melanin nanoparticles are harvested from black hair. These two kinds of nanoparticles are, respectively, embedded into the hemisphere of Janus microparticles by microfluidics technology. The in vitro tests reveal that the resultant Janus microparticles have high biocompatibility and show enhanced antioxidant performance and synergistical antibacterial activity. Additionally, when the Janus microparticles are applied to the treatment of diabetic wounds, they promote the wound healing by scavenging reactive oxygen species, killing bacteria, reducing inflammation, decreasing matrix metalloproteinase-9 secretion, and enhancing tissue remolding. Therefore, it is believed that the Janus microparticles with melanin and tea polyphenol-Mg nanoparticles are highly promising candidate for clinical wound healing.
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Registered trials
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