Evidence map›Paper›PMID 41256194›Full record

ArticleSmall science2025

Bicontinuous Interconnected Porous Biomaterials for Tissue Engineering and Regeneration.

Aihik Banerjee, Anjana Khanal, Prince D Okoro, Shankar P Kharal, Kevin Dalsania, Baishali Kanjilal, Shiril B Iragavarapu, Yiqing Chen, Janitha M Unagolla, Huinan H Liu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aihik BanerjeeDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.ORCID https://orcid.org/0000-0003-3022-0111
Anjana KhanalDepartment of Chemical Engineering Rowan University Glassboro NJ 08028 United States.
Prince D OkoroDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.
Shankar P KharalDepartment of Chemical Engineering Rowan University Glassboro NJ 08028 United States.ORCID https://orcid.org/0000-0001-5016-7499
Kevin DalsaniaDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.ORCID https://orcid.org/0009-0000-5886-9364
Baishali KanjilalDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.
Shiril B IragavarapuDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.
Yiqing ChenMaterials Science and Engineering Program University of California, Riverside Riverside CA 92521 United States.
Janitha M UnagollaDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.
Huinan H LiuDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.
Joshua T MorganDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.
Robert P HeskethDepartment of Chemical Engineering Rowan University Glassboro NJ 08028 United States.
Arash PezhoumanDepartment of Medicine Division of Cardiology Baylor College of Medicine Houston TX 77030 United States.
Reza ArdehaliDepartment of Medicine Division of Cardiology Baylor College of Medicine Houston TX 77030 United States.
Bahman AnvariDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.
Martin F HaaseVan't Hoff Laboratory of Physical and Colloid Chemistry Department of Chemistry Debye Institute for Nanomaterials Science Utrecht University 3584 Utrecht CS The Netherlands.
Iman NoshadiDepartment of Bioengineering University of California, Riverside Riverside CA 92521 United States.ORCID https://orcid.org/0009-0002-5632-3805

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomaterials mimicking natural extracellular matrix are necessary to create an optimal microenvironment for cell adhesion, migration, proliferation, and differentiation. These scaffolds must possess bicontinuous interconnected porosity to ensure the effective exchange of oxygen, nutrients, and metabolic waste, which are crucial for developing functional tissues. Here, a novel bicontinuous interfacially jammed emulsion (BIJEL)-Integrated PORous Engineered System (BIPORES) is developed to confer bioinert synthetic polyethylene glycol diacrylate (PEGDA) with unique bicontinuous interconnected porosity and surface topography. This platform is fabricated through controlled phase separation and interfacial stabilization of two continuous phases by nanoparticles. Functional validation using human mesenchymal stem cells, and human induced pluripotent stem cells-derived cardiomyocytes and cardiac fibroblasts, reveals outstanding cell attachment, growth, proliferation, and/or differentiation within tissue-scale BIPORES scaffolds. These findings indicate that bicontinuous interconnected porosity with negative Gaussian curvature in the BIPORES scaffolds plays a key role in organ-scale tissue engineering and regeneration.

Indexed as

bicontinuous materialshuman induced pluripotent stem cellsinterconnected porositypolyethylene glycol diacrylatesolvent transfer‐induced phase separation

Identifiers

PMID41256194
PMCPMC12622506

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.