Evidence map›Paper›PMID 41256179›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Spinal cord stimulation modulates post-synaptic inhibition improving neuromotor control of arm movement in people with chronic hemiparesis post-stroke.

Luigi Borda, Nikhil Verma, Erynn Sorensen, Erick Carranza, Roberto de Freitas, Scott Ensel, Amy Boos, Peter C Gerszten, Daryl P Fields, George F Wittenberg and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Luigi BordaNeuroMechatronics Lab, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0009-0003-4670-8530
Nikhil VermaNeuroMechatronics Lab, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0009-0004-5533-6887
Erynn SorensenRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0988-4132
Erick CarranzaRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-8502-3222
Roberto de FreitasRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4169-5692
Scott EnselRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-0264-3686
Amy BoosRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
Peter C GersztenDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1483-6090
Daryl P FieldsRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.
George F WittenbergRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-5603-1197
Lee E FisherRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-9072-3119
Elvira PirodiniRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-8078-3951
Marco CapogrossoRehabilitation and Neural Engineering Labs, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-0975-316X
Douglas J WeberNeuroMechatronics Lab, Carnegie Mellon University, Pittsburgh, PA, USA.ORCID 0000-0002-9782-3497

Funding

Spinal Cord Stimulation to Improve Motor Function in People with Post-Stroke HemiplegiaUG3NS123135 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CAPOGROSSO, MARCO, WEBER, DOUGLAS J · 2022 to 2024
$4.7M
NINDS NIH HHS UG3 NS123135
6 · The paper itself

Abstract

Epidural spinal cord stimulation has been shown to be a promising neurotechnology to improve upper limb function in people affected by stroke. It is well established that SCS targeting the dorsal root entry zone increases excitatory drive to α-motoneurons via the monosynaptic reflex pathway. However, the effects of SCS on inhibitory neural pathways remain unexplored. We hypothesized that SCS improves the neuromotor control of arm movement by strengthening both excitatory and inhibitory circuit function. We show in three individuals with post-stroke motor symptoms that SCS enhances postsynaptic Ia reciprocal inhibition. These changes correlate with enhanced muscle coordination and arm kinematics resulting in smoother and faster trajectories. Our study provides further insights into the neural targets of spinal cord stimulation and the use of this technology to treat post-stroke motor deficits.

Identifiers

PMID41256179
PMCPMC12622153

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.