Evidence map›Paper›PMID 41256171›Full record

ArticlemedRxiv : the preprint server for health sciences2025

DNA Methylation Profiling in Childhood-Onset Lupus Reveals Distinct Epigenetic Clusters and Suggests Epigenetic Drivers of Disease Activity.

Desiré Casares-Marfil, Gülşah Kavrul Kayaalp, Vafa Guliyeva, Özlem Akgün, Şeyma Türkmen, Elif Kılıç Könte, Seher Şener, Sezgin Şahin, Özgür Kasapçopur, Betül Sözeri and 4 more

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In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Desiré Casares-MarfilDivision of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, USA.
Gülşah Kavrul KayaalpDivision of Rheumatology, Department of Pediatrics, University of Pittsburgh, Pittsburgh, USA.
Vafa GuliyevaDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Özlem AkgünDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Şeyma TürkmenDivision of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Umraniye Research and Training Hospital, Istanbul, Turkey.
Elif Kılıç KönteDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Seher ŞenerDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Sezgin ŞahinDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Özgür KasapçopurDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Betül SözeriDivision of Pediatric Rheumatology, Department of Pediatrics, University of Health Sciences, Umraniye Research and Training Hospital, Istanbul, Turkey.
Selçuk Sözer TokdemirDepartment of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
Seza ÖzenDivision of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Nuray Aktay AyazDivision of Pediatric Rheumatology, Department of Pediatrics, Istanbul University Faculty of Medicine, Istanbul, Turkey.
Amr H SawalhaDepartments of Pediatrics, Medicine, and Immunology, Lupus Center of Excellence, University of Pittsburgh School of Medicine, Pittsburgh, USA.ORCID 0000-0002-3884-962X

Funding

Role of DNA methylation in lupusR01AI097134 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Amr H Sawalha · 2013 to 2026
$4.5M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
NIAID NIH HHS R01 AI097134NIH HHS S10 OD028483
6 · The paper itself

Abstract

Objectives: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organs, with childhood-onset SLE (cSLE) typically presenting a more severe course and greater genetic risk than adult-onset SLE. While DNA methylation plays a key role in lupus pathogenesis, the epigenetic landscape of cSLE remains understudied. This study aimed to investigate DNA methylation changes in cSLE. Methods: A total of 64 cSLE patients and 47 healthy control DNA samples isolated from peripheral blood mononuclear cells (PBMCs), along with an independent validation cohort of 38 patient DNA samples from whole blood, were analyzed. DNA methylation was assessed using the Infinium MethylationEPIC v2.0 array (Illumina), with quality control and statistical analyses performed using the Results: Differential methylation analysis revealed significant hypomethylation in interferon-regulated genes (e.g., Conclusion: cSLE displays distinct DNA methylation patterns associated with disease activity, molecular subgroups, and sex, underscoring the potential for epigenetically informed diagnostics and therapies.

Indexed as

childhood-onsetDNA methylationepigeneticsLupuspediatricSLE

Identifiers

PMID41256171
PMCPMC12622076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.