Evidence map›Paper›PMID 41256169›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Bismuth subsalicylate profoundly alters gut microbiome and immunity with increased susceptibility to infection.

Victor I Band, Phoebe LaPoint, Shira Levy, Lauren Krausfeldt, Ian S Lacroix, Audrey Chong, Nathan T Brandes, Benjamin Schwarz, Shreni Mistry, Andrew S Burns and 24 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Victor I BandClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-9288-0188
Phoebe LaPointClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0009-0004-9471-3104
Shira LevyClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0009-0005-8240-925X
Lauren KrausfeldtBioinformatics and Computational Biosciences Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-7405-427X
Ian S LacroixResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, United States.ORCID 0000-0002-4859-7024
Audrey ChongResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, United States.
Nathan T BrandesResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, United States.ORCID 0009-0001-6958-9285
Benjamin SchwarzResearch Technologies Branch, National Institute of Allergy and Infectious Diseases, Division of Intramural Research, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, Montana, United States.ORCID 0000-0002-5894-953X
Shreni MistryNIAID Microbiome Program, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Andrew S BurnsNIAID Microbiome Program, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Mickayla BacornClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0003-2110-7985
Keona BanksClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Rachel StrengthClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0002-6306-1228
Qing ChenClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Hector N Romero-SotoClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-9566-0930
Ruhika PrasadClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Richard AppsNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.
Liya WangNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.
Iyadh DouagiNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.ORCID 0000-0002-3221-8667
Jessie J PolancoNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.
Aparna KotekarNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.
Amrita MukherjeeNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.
Galina KorolevaNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.
Ashley CompeanNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.
Brian SellersNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.
Thomas LangowskiNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.ORCID 0009-0005-8096-9659
Kevin RoseNIH Center for Human Immunology, Autoimmunity, and Inflammation (CHI), Bethesda, Maryland, United States.ORCID 0000-0003-1537-5481
Susan RoyClinical Center, National Institutes of Health, Bethesda, Maryland, United States.
Sivaranjani NamasivayamClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
P Juliana Perez-ChaparroNIAID Microbiome Program, Laboratory of Host Immunity and Microbiome, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Joanna ChauMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0003-3894-3525
Apollo StacyMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0001-7477-5552
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Suchitra K HouriganClinical Microbiome Unit, Laboratory of Host Immunity and Microbiome, Division of Intramural Research National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States.ORCID 0000-0003-2656-5694

Funding

Role of sulfide in oral microbiota-host interactions that promote periodontitisR00DE031372 · NIDCR · CLEVELAND CLINIC LERNER COM-CWRU · PI STACY, APOLLO · 2023 to 2025
$908k
Role of nitrate in microbiota ecologyR35GM160210 · NIGMS · CLEVELAND CLINIC LERNER COM-CWRU · PI Apollo Stacy · 2025 to 2026
$886k
NIDCR NIH HHS R00 DE031372NIGMS NIH HHS R35 GM160210
6 · The paper itself

Abstract

Bismuth subsalicylate (BSS) is a commonly used over-the-counter medication for a variety of gastrointestinal symptoms. BSS sequesters gut sulfides, which have been shown in murine studies to be key regulators of gut microbiota. Here, we investigated the impact of BSS on human gut microbiome, immunity and susceptibility to enteric pathogens. We observed a significant shift in microbiome composition after BSS usage, with a profound expansion in bacteria with pathogenic potential including Pseudomonadota. Metabolite composition was greatly altered with increased amino acid levels and decreased short chain fatty acids and secondary bile acids. Notably, there was a collapse of key CD4 T cell subsets in the ileum. Finally, mouse and

Identifiers

PMID41256169
PMCPMC12622087

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