ArticlemedRxiv : the preprint server for health sciences2025
Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: C-reactive protein (CRP) is a well-established biomarker of systemic inflammation. In pregnancy, several studies show association of elevated CRP with gestational diabetes mellitus (GDM). However, the genetic contributions of CRP levels during early pregnancy and their potential association with GDM remain largely understudied. Methods: We conducted maternal and offspring genome-wide association studies (GWAS) of first-trimester CRP levels in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) cohort. Genetic correlation between CRP and GDM was assessed using linkage disequilibrium score regression (LDSC), and polygenic risk scores (PRS) of CRP were further evaluated for associations with GDM. Results: In the European maternal sub-cohort of nuMoM2b, three genome-wide significant loci ( Conclusions: Our findings validate known genetic loci regulating systematic inflammation in a cohort of pregnant individuals, correlating with serum CRP levels, and highlight the value of pregnancy-specific GWAS in uncovering unique biological pathways relevant to maternal-fetal health.
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