Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
17 authors.
Patricia Agudelo-RomeroWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0002-3703-4111
Thomas IosifidisWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0001-8462-5865
James LimWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.
Nina KresojeWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0009-0008-7104-3362
David G HancockWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0003-4782-2661
Guicheng ZhangWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0001-9888-5385
Abhinav SharmaDSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7700, South Africa.ORCID 0000-0002-6402-6993
Talya ConradieWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0009-0007-6380-5737
Yuliya V KarpievitchWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0003-2586-3358
Desiree T SilvaMedical School, The University of Western Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0003-4454-466X
Anthony BoscoAsthma and Airway Disease Research Center University of Arizona, Tucson, 85721, Arizona, United States.ORCID 0000-0002-4335-615X
Susan L PrescottMedical School, The University of Western Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0003-4845-8590
Peter N LeSouëfWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.
Elizabeth Kicic-StarcevichWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0009-0002-9113-8939
Anthony KicicWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0002-0008-9733
David J MartinoWal-yan Respiratory Research Centre, The Kids Research Institute Australia, Perth, 6009, Western Australia, Australia.ORCID 0000-0001-6823-4696
Stephen M StickDepartment of Respiratory and Sleep Medicine, Perth Children's Hospital Perth, Perth, 6009, Western Australia, Australia.ORCID 0000-0002-5386-8482
Funding
TRANSCRIPTIONAL REGULATION OF ANTIBODY RESPONSES AND IMMUNITYR01AI099108 · NIAID · WASHINGTON UNIVERSITY · PI Deepta Bhattacharya · 2012 to 2026
$6.4M
Systemic and intercellular gene networks underlying RV-induced airways diseaseR21AI176305 · NIAID · UNIVERSITY OF ARIZONA · PI BOSCO, ANTHONY · 2023 to 2024
Background: Dysregulation of the airway epithelium contributes to recurrent wheezing and asthma and may have developmental origins. Here, we investigated the relationship between the placental amniotic and nasal epithelial methylation landscapes to determine whether amniotic epithelium provides insight into fetal programming of respiratory tissue. Methods: We conducted high-throughput target-capture DNA methylation sequencing of 84 matched pairs of placental amniotic and neonatal nasal brushings samples within the Airway Epithelium Respiratory Illnesses and Allergy (AERIAL) cohort. Comparative analysis of tissue-specific methylation profiles, and conservation of methylation changes associated with gestational exposures (maternal smoking and maternal asthma), was explored. Results: Between amniotic and nasal tissues, we identified 4,897 differentially methylated regions (FDR ≤ 0.05 and log Conclusions: The conserved methylome signatures support the use of amniotic tissue as a valuable tissue for investigating the developmental programming of airway vulnerability, potentially leading to early risk stratification and targeted interventions for childhood asthma.
Indexed as
1.12 Clinical asthma1.17 Epidemiology (Pediatric): Risk Factors < PEDIATRICS3.02 Bioinformatics/Biological Computing < CELL AND MOLECULAR BIOLOGY3.05 Epigenetics < CELL AND MOLECULAR BIOLOGY3.40 Airway epithelium < CELL AND MOLECULAR BIOLOGYairwayamnionasthmaDNA methylationepigeneticsEpitheliumEWASexposuresin-uterosmoking
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Programming of the respiratory epithelium · full record | OpenQuestion